Spectrophotometric techniques were developed for the determination of single and binarymixture Promethazine hydrochloride (PMH) and Paracetamol (PCM). Normal and first derivative (D) used for single drug at λ 249.5 and 243.0 for PMH and 243.5 and 225 for PCM. The simultaneous determination of binary mixture (PMH) and (PCM) were accomplished by first derivative (D) and second derivative (D) spec...

This report summarizes some trends observed in drug dissolution testing, based upon the United States Pharmacopeia (USP) dissolution Apparatus Suitability Test results and the preliminary data obtained from an international collaborative study to assess the pharmaceutical quality of furosemide products in different countries. Based on the USP calibrator data submitted by the participants, repre...

Safe and effective paediatric pharmacotherapy requires careful evaluation of the type of drug substance, the necessary dose and the age-appropriateness of the formulation. Generally, the younger the child, the more the attention that is required. For decades, there has been a general lack of (authorised) formulations that children are able to and willing to take. Moreover, little was known on t...

A nondestructive transmittance near-infrared (NIR) method for detecting off-centered cores in dry-coated (DC) tablets was developed as a monitoring system in the DC tableting process. Caffeine anhydrate was used as a core active pharmaceutical ingredient (API), and DC tablets were made by the direct compression method. NIR spectra were obtained from these intact DC tablets using the transmittan...

Sodium monofluorophosphate (MFP, CAS 10163-15-2), widely used as an anti-caries agent and in the prevention or treatment of osteoporosis, is sensitive to moisture and acid. This research presents results of a study of the stability of MFP in tablets from four different pharmaceutical laboratories. With an initial water content of 2.9 to 4.0%, the pH of water solutions of three brands of non-eff...

This study was supported by MSM2678846201 and GACR 523/02/0164. For experiments in area of dairy cows amino acid nutrition the ruminaly protected tablets containing protein, free amino acids or mix of them has been developed. In consequence of their size (>5 mm) an unneglible part of them can be regurgitated. The proportion of regurgitated particles and their passage rate through the GI tract a...

Background Ensuring adherence to prescribed smoking cessation medications, such as Champix® (varenicline), is essential during a quit attempt as non-adherence can significantly reduce the likelihood of achieving prolonged smoking abstinence. The use of dose administration aids may improve adherence, though medication stability on repackaging is not guaranteed, due to a lack of available data fr...

The main objective of this study is to explore development of pharmaceutical excipients from the husk obtained from the seeds of Plantago ovata. Husk shows very good swelling property in water due to the major part of mucilage in it. Since swelling is one of the mechanisms of action of some tablet disintegrants, it is thought that the husk powder of Plantago ovata would be able to act as a tabl...