Over the last decade, generic penetration in the U.S. pharmaceutical market has increased substantially, providing significant consumer surplus gains. What impact has this rise in generic penetration had on the rate and direction of early stage pharmaceutical innovation? We explore this question using novel data sources and an empirical framework that models the flow of early-stage pharmaceutic...

in this work, the optimization calculations were carried out on quetiapine hemifumarat, 4, and its analogues, 1-5. these calculations were carried out using the b3lyp/6-31g(d) level of theory. the dft calculations clarified a boat structure for dibenzothiazepine moiety of the molecule which piperazine moiety has a chair conformation. thermal energies (e), enthalpies (h), and free energies (g) o...

this commentary explores the implications of increased social media marketing by drug manufacturers, based on findings in hyosun kim’s article of the major themes in recent food and drug administration (fda) warning letters and notices of violation regarding online direct-to-consumer promotions of pharmaceuticals. kim’s rigorous analysis of fda letters over a 10-year span highlights a relative ...

this paper discussed the application of information and communication technology (ict) in pharmaceutical product marketing in nigeria. data for the study was obtained from 76 pharmaceutical firms in southwest nigeria which comprised of about 95% of the pharmaceutical companies that were into manufacturing of drugs in nigeria. the categories of firms surveyed include retail pharmacy, combination...

background: acute poisoning is a major public health problem in bangladesh. it is a common method for suicide. a clear picture regarding clinical presentation, most commonly used toxic agents, background factors and outcome of poisoned patients is necessary in every region. the aim of this study was to investigate frequency and outcome of acute pharmaceutical and chemical poisoning cases in nor...

a simple, sensitive and accurate method for spectrophotometric determination of dalacinphosphatehas been established. the method is based on the reduction of atomic absorptioncalcium ion by phosphate. because, there is a phosphate mole in every dalacin mole structureand with measurement of phosphate, dalacin is beyond measurement too. therefore, the reactionbetween acidic hydrolysis products of...

to be sure, all the industries try to be involved in globalization with a constant trend to find out ways to increase productivity across different functions within an organization to maintain competitive advantage world. pharmaceutical industries are not exceptional and further are based on fragmentation. so these kind of companies need to cope with several barriers such as silo mentality that...

one hundred and fifteen prescriptions which were purposely written in toxic and potentially fatal dose of different medicine (mainly digitoxin) were sent to pharmacies throughout iran. all pharmacies filled up the prescription and only one pharmacist made notice of dangerous dose. the pharmacist in the drugstores in iran is forcefully employed by the owner of the pharmacy which is required by l...

This Application Bulletin describes an approach for developing near-infrared methods for the determination of residual moisture in typical lyophilized pharmaceutical products. In this case, samples were contained in sealed 30 mL serum vials (3 cm o.d.). The average cake weight of this product was 1.6 g with a target moisture level of 1% and acceptable moisture limit of not more than 2% by weigh...

This Application Bulletin describes an approach for developing near-infrared methods for the determination of residual moisture in typical lyophilized pharmaceutical products. In this case, samples were contained in sealed 30 mL serum vials (3 cm o.d.). The average cake weight of this product was 1.6 g with a target moisture level of 1% and acceptable moisture limit of not more than 2% by weigh...