Four endemic human coronaviruses (HCoVs) are commonly associated with acute respiratory infection in humans. B cell responses to these “common cold” viruses remain incompletely understood. Here we report a comprehensive analysis of CoV-specific antibody repertoires 231 children and 1168 adults using phage immunoprecipitation sequencing. Seroprevalence antibodies against HCoVs ranged between app...

Streptococcus mutans is a key bacterium in dental caries, one of the most prevalent chronic infectious diseases. Conventional treatment fails to specifically target pathogenic bacteria, while tending eradicate commensal bacteria. Thus, caries remains common and challenging Phage therapy, which involves use bacterial viruses as anti-bacterial agents, has been gaining interest worldwide. Neverthe...

in this study, 90 internal organ samples of poultry with symptoms of colibacillosis were obtained from maragheh poultry farms in east azerbaijan, iran. in total, 70 bacterial isolates were confirmed as escherichia coli (e. coli) strains using standard biochemical tests, and antibiotic sensitivity was determined by the disk diffusion method. antibiotics used in this study included ampicillin, pe...

Abstract Background Microbe–virus interactions have broad implications on the composition, function, and evolution of microbiomes. Elucidating effects environmental stresses these is critical to identify ecological function viral communities understand microbiome adaptation. Heavy metal-contaminated soils represent a relevant ecosystem study interplay between microbes, viruses, stressors. Resul...

In the context of bacteriophage (phage) therapy, there is an urgent need for a method permitting multiplexed, parallel phage susceptibility testing (PST) prior to formulation personalized cocktails administration patients suffering from antimicrobial-resistant bacterial infections. Methods based on surface plasmon resonance imaging (SPRi) and phase were demonstrated as candidates very rapid (&l...

The serological analysis of antigens by recombinant expression cloning (SEREX) has identified a multitude of new tumor antigens in many different tumor entities. These antigens can be grouped into different classes according to their specificities, with cancer/testis antigens appearing to be the most attractive candidates for vaccine development. The observation that CD8 and CD4 T-cell response...

“Jumbo phages” are an emergent and ubiquitous class of large (>200 kb) dsDNA bacteriophages—viruses that infect bacteria—that construct a selectively-permeable, proteinaceous compartment around their replicating genome during infection. This micron-scale compartment, termed the “phage nucleus”, forms de novo grows with viral DNA. The phage nucleus allows export mRNA import select DNA replicatio...

objectives: evaluation of therapeutic effects of carum copticum (c. copticum) has been the subject of several studies in recent years. thymol the major component of c. copticum is a widely known anti-microbial agent. in this study, the antibacterial and anti viral activities of essential oil of c. copticum fruit were determined. materials and methods: essential oil of c. copticum was analyzed b...