Institute of Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Portugal In order to ensure the safe usage of new radiopharmaceuticals in Positron Emission Tomography (PET), it is necessary to quantify the doses delivered to the organs and tissues within the patients’ bodies. A framework that allows estimating the dose delivered by PET has been established by the MIRD Committee ...

The X-Ray CT scanner and MRI imaging of the brain have changed the study of this organ, in health and in disease. To add to the detailed demonstration of anatomy, functional imaging of the human brain is now carried out by either positron emission computed tomography (PET) or by single photon emission computed tomography (SPET). PET allows for the investigation of brain blood flow, metabolism a...

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Peripheral sterile inflammatory diseases (PSIDs) are a heterogeneous group of disorders that gathers several chronic insults involving the cardiovascular, respiratory, gastrointestinal, or musculoskeletal system and wherein inflammation is the cornerstone of the pathophysiology. In PSID, timely characterization and localization of inflammatory foci are crucial for an adequate care for patients....

Fluorine-18-fluorodeoxyglucose- positron emission tomography ((18)F-FDG PET) in head and neck cancer patients is useful for staging, identification of macroscopic disease, detection of invaded lymph nodes and distant metastases, delineation of radiotherapy target volume and assessment of treatment response. This brief review addresses the potential role of PET in radiotherapy planning as compar...

introduction range and diffusion of positron-emitting radiopharmaceuticals are important parameters for image resolution in positron emission tomography (pet). in this study, geant4 toolkit was applied to study positron diffusion in soft tissues with and without a magnetic field for six commonly used isotopes in pet imaging including 11c, 13n, 15o, 18f, 68ga, and 82rb. materials and methods gea...

Over the past decade, theragnostic radiopharmaceuticals have been used in nuclear medicine for both diagnosis and treatment of various tumors. In this review, we carried out a literature search to investigate explain role radiotracers approach glioblastoma multiform (GBM). We primarily focused on basic rather common positron emotion tomography (PET) these Subsequently, introduced evaluated prec...

In recent years, radiometals have been successfully applied to medicine because of their breadth decay properties and increased production availability. Bifunctional chelators play a key role in radiometal-based radiopharmaceuticals, affecting the labeling, targeting, pharmacokinetics bioconjugations ensuring stable complexation metal vivo. The capacity macrocycles form complexes with extremely...

Materials, known as radiopharmaceuticals, are intro.The use of specific radiotracers called radiopharmaceuticals for imaging organ function and disease states is a unique capability of nuclear medicine.nuclear medicine. The manual describes the requirements for safe preparation and quality control of radiopharmaceuticals. In addition, it contains essential.important factors common to most nucle...