نتایج جستجو برای: peroxisome proliferator activated receptors
تعداد نتایج: 423823 فیلتر نتایج به سال:
In this study we investigated if peroxisome proliferator-activated receptor β/δ activation protects from copper-induced acute liver damage. Mice treated with copper had significant body weight loss, serum alanine aminotransferase increase, modest changes in liver histology, increase of tumor necrosis factor α and macrophage inflammatory protein 2 mRNA and 8-hydroxy-2'-deoxyguanosine. Mice treat...
1 Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, Miyagi 980-8574, Japan Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, Sendai, Miyagi 980-8574, Japan Department of Molecular Microbiology and Immunology, Keck School of Medicine, University Southern California, Los Angeles, CA ...
Magdalena Sastre,1 Ilse Dewachter,2 Gary E. Landreth,3 Timothy M. Willson,4 Thomas Klockgether,1 Fred van Leuven,2 and Michael T. Heneka1 1Department of Neurology, University of Bonn, 53127 Bonn, Germany, 2Department of Human Genetics, Experimental Genetics Group, B-3000 Leuven, Belgium, 3Alzheimer Laboratory, Case Western Reserve University, Cleveland, Ohio 44106-4928, and 4GlaxoSmithKline, Di...
in this presentation, we review briefly on biogenesis of peroxisomes with regard to the recent findings on biogenesis. peroxisomes perform a range of various functions as oxidation of very long chain fatty acids, generation and removal of hydrogen peroxide, while peroxisomes have also been implicated in β-oxidation of aromatic and cyclic compounds, synthesis of plasmalogens, isoprenoids, lysine...
The peroxisome proliferator-activated receptors (PPARs) regulate genes involved in lipid and carbohydrate metabolism, and are targets of drugs approved for human use. Whereas the crystallographic structure of the complex of full length PPARγ and RXRα is known, structural alterations induced by heterodimer formation and DNA contacts are not well understood. Herein, we report a small-angle X-ray ...
a Dipartimento di Scienze del Farmaco, Università “G. D'Annunzio”, Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo, Italy b Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, United States c Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, ...
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