Stimulation of cell proliferation caused by peroxisome proliferators was blocked by antibodies against TNF alpha and agents that inactivate Kupffer cells, a rich source of TNF alpha, which supports the hypothesis that Kupffer cells play a pivotal role in peroxisome proliferator-induced hyperplasia. Here, the ability of the very potent peroxisome proliferator WY-14 643 to activate the transcript...

The enzymes required for the beta-oxidation of fatty acyl-CoA are present in peroxisomes and mitochondria. Administration of hypolipidaemic compounds such as clofibrate to rodents leads to an increase in the volume and density of peroxisomes in liver cells. These proliferators also induce simultaneously the expression of genes encoding acyl-CoA oxidase, enoyl-CoA hydratase-hydroxyacyl-CoA dehyd...

The standard treatment for aPBC is to combine a fibrate with UDCA. Bezafibrate and fenofibrate are fibrates that elevate serum creatinine levels while decreasing the estimated glomerular filtration rate (eGFR). Pemafibrate selective peroxisome proliferator-activated receptor α modulator, which primarily metabolized by liver. This study assessed effects of switching from pemafibrate in 16 patien...