BACKGROUND Lentigo maligna (LM) commonly presents as a slow-growing pigmented macular lesion in chronically sun-damaged skin and may progress to invasive melanoma. Many regard it as a subtype of melanoma in situ (MIS), and surgical excision remains the preferred treatment, but standard 5-mm surgical margins recommended for typical MIS are often insufficient for LM due to its indistinct borders ...

We argued in our article, Patent Holdup and Royalty Stacking, that the threat to obtain a permanent injunction can greatly enhance a patent holder’s negotiating power, leading to royalty rates that exceed a benchmark level based on the value of the patented technology and the strength of the patent. Our analysis showed that such problems are especially likely to arise for patents covering a min...

OBJECTIVE In a double blind prospective clinical study to evaluate the diagnostic potential of peroperative fine needle aspiration cytology as compared to peroperative frozen section in thyroid surgery. METHODS The diagnostic value of one hundred consecutive preoperative (FNA) and peroperative fine needle aspiration (p-FNA), frozen section (FS) and permanent section (PS) examination for thyro...

TIA was originally defined as a sudden onset of a focal neurologic symptom and/or sign lasting less than 24 hours and caused by reversible cerebral ischemia. However, this classic definition of TIA was inadequate for several reasons. Most notably, there is risk of permanent tissue injury (ie, infarction) even when focal transient neurologic symptoms last less than one hour. Furthermore, about o...

M.D., F.R.C.P. Ed. Pp. xvi., 640. Edinburgh : Young J. Pentland. 1892. There is no doubt that this book will take a permanent place as a standard work on throat, nose, and ear disease. The author deals especially fully with the diagnosis and treatment of ear disease, and nearly three hundred pages are devoted to this section. Of this we are very glad, as we believe that the man who can examine ...

Two-photon spectroscopy of fluorescent proteins is a powerful bio-imaging tool characterized by deep tissue penetration and little damage. However, two-photon spectroscopy has lower sensitivity than one-photon microscopy alternatives and hence a protein with a large two-photon absorption cross-section is needed. We use time-dependent density functional theory (TD-DFT) at the B3LYP/6-31+G(d,p) l...

Various methods were devised in attempts to produce chronic hypertension in dogs. The induction of anxiety was unsuccessful. Bilateral renal denervation combined with injections of epinephrine appeared to produce temporary hypertension. Permanent hypertension was induced by unilateral renal ischemia with the other kidney left intact only in dogs of nervous temperament. Certain dogs were extreme...

Non-scaling, non-factorizing 1 Q2 I contributions to cross sections are derived for semi-inclusive deep-inelastic scattering, RN+ R'?TX. These higher twist terms are dominant at large z=p; pN /Q l pN. They provide unusual (l-y) terms in the cross section, as well as asymmetries in the azimuthal angle dependence. Calculations are also presented for the quark to pion fragmentation function (Submi...

Cats after unilateral bulbar pyramid section showed permanent loss of tactile placing in the contralateral limbs. However, the cats could be trained to place the forelimb following light touch in a conditioning situation with food as a reward. Subsequent unilateral or bilateral cerebral cortical lesions involving sensory and/or motor areas did not abolish this conditioned response. Since these ...