Hematopoietic stem-cell transplantation (HSCT) refers to a procedure in which hematopoietic stem cells are infused to restore bone marrow function in cancer patients who receive bone-marrowtoxic doses of cytotoxic drugs, with or without whole body radiation therapy. Stem cells may be obtained from the transplant recipient (autologous HSCT) or can be harvested from a donor (allogeneic HSCT). Ste...

Hematopoietic stem cell transplantation (HSCT) is widely used to treat hematological malignancies and nonmalignant disorders. Many advances have been made in improving the success of bone marrow transplantation. However, lack available matched related or sibling donors has posed a significant challenges availability proper utilization hematopoietic patients with malignancies. The rising alterna...

background: stem cell therapy is a new treatment option for different diseases. the aim of this systematic review is assessing the articles that focus on sct in iran and evaluate the amount of their success, failure and complication. methods: systematic search was conducted for finding english and persian papers (controlled trials and cohort studies with follow up) published before march 2015. ...

the increased risk of hemolytic reactions and erythrocyte recovery delay in abo incompatible hematopoietic stem cell transplantation (hsct) is well established. effects of abo incompatibility on transplantation outcomes is evaluated in this study. we prospectively followed 501 patients undergoing allogeneic stem cell transplantation according to abo compatibility groups of minor, major and bidi...

Autologous peripheral blood stem cell transplantation High dose myeloablative treatment followed by autologous haemopoietic stem cell rescue is increasingly used in the treatment of haematological malignancies and solid tumours with the aim of achieving a dose–response eVect. Apart from the risk of disease relapse, the major drawback of this approach is the risk of procedure related toxicity re...

Background: There is a worldwide effort to present novel approaches for the development of tolerance-induction treatments in regenerative medicine, after years of investigation in clinical transplantation. Particularly, novel approaches are based on controlling the immune response, including the application of biomaterials or imitation of antigen-specific peripheral tolerance in either solid-or...