We examined the ability of local anesthetics to correct altered inactivation properties of rat skeletal muscle Na+channels containing the equine hyperkalemic periodic paralysis (eqHPP) mutation when expressed in Xenopusoocytes. Increased time constants of current decay in eqHPP channels compared with wild-type channels were restored by 1 mM benzocaine but were not altered by lidocaine or mexile...

Neurology S. L. Venance, K. Jurkat-Rott, F. Lehmann-Horn and R. Tawil SCN4A-associated hypokalemic periodic paralysis merits a trial of acetazolamide This information is current as of November 24, 2007 http://www.neurology.org/cgi/content/full/63/10/1977 located on the World Wide Web at: The online version of this article, along with updated information and services, is All rights reserved. Pri...

Although serum potassium levels are usually subnormal in Thyrotoxic Periodic Paralysis (TPP), but in exceptionally rare circumstances, it may be normal leading to the entity called normokalemic TPP. The diagnosis of normokalemic TPP is more often overlooked and/or delayed due to lack of awareness among the physicians and associated mild symptoms of hyperthyroidism. Here, the author describes th...

Thyrotoxic periodic paralysis is a disease characterized by recurrent episodes of paralysis and hypokalemia during a thyrotoxic state. Thyrotoxic periodic paralysis is a common complication of hyperthyroidism in Asian populations, but can affect other ethnic groups as well. Due to population mobility, Thyrotoxic periodic paralysis is increasingly common in Western countries. Early diagnosis and...

Let X be a topological space (an "accessible space," a "1-space," or a " TV-space " in the terminology of Fréchet, Kuratowski, or Alexandroff-Hopf, respectively) and let f(X) = X be a homeomorphism. We use the following terminology, which was suggested by G. A. Hedlund and which is to be carefully distinguished from those terminologies used by Birkhoff, Ayres, Whyburn, and others. A point x of ...

Thyrotoxic periodic paralysis (TPP) is a rare manifestation of hyperthyroidism characterized by muscle weakness and hypokalemia. All ethnicities can be affected, but TPP typically presents in men of Asian descent. The most common cause of TPP in thyrotoxicosis is Graves' disease. However, TPP can occur with any form of thyrotoxicosis. Up to our knowledge, very few cases ever reported the relati...

Objective. Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of Graves' disease (GD). The present study compared the long-term efficacy of antithyroid drugs (ATD), radioactive iodine (RAI), and surgery in GD/TPP. Methods. Sixteen patients with GD/TPP were followed over a 14-year period. ATD was generally prescribed upfront for 12-18 months before RAI or surgery ...

ultra-short pulse is a promising technology for achieving ultra-high data rate transmission which is required to follow the increased demand of data transport over an optical communication system. therefore, the propagation of such type of pulses and the effects that it may suffer during its transmission through an optical waveguide has received a great deal of attention in the recent years. we...

The spectral properties of the Schrr odinger operator T t y = ?y 00 + q t y in L 2 (R) are studied, with a potential q t = p 1 (x); x < 0; and q t = p(x + t); x > 0; where p 1 ; p are periodic potentials and t 2 R is a parameter of the dislocation. Under some conditions there exist simultaneously gaps in the continuous specrum of T 0 and eigenvalues in these gaps. The main goal of this paper is...

We show how to stabilize the uniform oscillations of the complex Ginzburg–Landau equation with periodic boundary conditions by means of some global delayed feedback. The proof is based on an abstract pseudo-linearization principle and a careful study of the spectrum of the linearized operator.