conclusions the analysis of the pro-apoptotic gene to anti-apoptotic gene expression ratio (bad /bcl-xl) confirmed that expression of the pro-apoptotic gene significantly decreased (p value ˂ 0.001) under the ischemia/reperfusion condition. in contrast, the expression of the anti-apoptotic gene increased after administration of fk-506 (p value ˂ 0.001). results the quantitative results of real-...

Introduction: There are several different molecular pathways in tissue damage by Ischemic Brain Injury. The use of antioxidants and free radical scavengers are a matter of attention by some researchers. Crocus sativus (saffron) is used previously for protective effects in ischemia state by some researchers. To assess pathologic aspects of neuroprotection of saffron in some susceptible brain are...

conclusions opium was not identified as a risk factor of ischemic stroke. a more extended survey considering further confounding factors is recommended. background one of the supposed risk factors of ischemic stroke is opium addiction, while the researches about its prevalence among patients with stroke are limited. objectives the aim of this study was comparing the prevalence of opium addictio...

background: it is not clear whether the latest activation sites in the left ventricle (lv) are matched with infracted regions in patients with ischemic cardiomyopathy (icm). we aimed to investigate whether the latest activation sites in the lv are in agreement with the region of akinesia in patients with icm.   methods: data were analyzed in 106 patients (age = 60.5 ± 12.1 y, male = 88.7%) with...

conclusions ferulago angulata extract, because of its antioxidant activities, is probably capable of removing free radicals and oxidant substances from brain and thus it can improve behavioral disorders in brain hypoperfusion ischemia model. results it was found that the administration of 400 mg/kg hydroalcoholic extract of f. angulate for two weeks after brain hypoperfusion ischemia increased ...

background: the role of nitric oxide (no) of endothelial or neuronal origins in cerebral ischemia and reperfusion injuries are far from being settled, extending from being important to not having any role at all.    objective: to investigate the role of no of endothelial and neuronal origins in ischemia/reperfusion injuries in focal cerebral ischemia, l-name, a non selective no synthase inhibit...

objective(s):ischemia is described as organs and tissues are destitute of oxygen due to decreased arterial or venous blood flow. many mechanisms play role in cell death happened as a consequence of a new blood flow is needed for both cell regeneration and to clean toxic metabolites during ischemia and later. lung damage induced by ischemia/reperfusion (i/r) is a frequent problem in lung transpl...

objectives:vagal pathways in gastrointestinal tract are the most important pathways that regulate ischemia/reperfusion (i/r).  gastrointestinal tract is one of the important sources of melatonin production. the aim of this study was to investigate probable protective effect of the interaction between vagus nerve and melatonin after i/r. materials and methods:this study was performed in male rat...

myocardial infarction is a common presentation of coronary artery disease and the leading cause of death worldwide. the present study was investigated potential resistance to ischemia-reperfusion (i/r) injuries following administration of methanolic (meoh) extract of scrophularia frigida (s. frigida) in isolated rat heart. male wistar rat hearts (n= 8-10) were isolated and allowed to equilibrat...