We consider statistical and algorithmic aspects of solving large-scale least-squares (LS) problems using randomized sketching algorithms. Prior results show that, from an algorithmic perspective, when using sketching matrices constructed from random projections and leverage-score sampling, if the number of samples r much smaller than the original sample size n, then the worst-case (WC) error is...

Animal studies have found that the phasic activity of dopamine neurons during reward-related learning resembles a "prediction error" (PE) signal derived from a class of computational models called reinforcement learning (RL). An apparently similar signal can be measured using fMRI in the human striatum, a primary dopaminergic target. However, the fMRI signal does not measure dopamine per se, an...

Performance monitoring is crucial for well-adapted behavior. Offenders typically have a pervasive repetition of harmful-impulsive behaviors, despite an awareness of the negative consequences of their actions. However, the link between performance monitoring and aggressive behavior in juvenile offenders has not been closely investigated. Event-related brain potentials (ERPs) were used to investi...

When we respond to a stimulus, our decisions are based not only on external stimuli but also on our ongoing performance. If the response deviates from our goals, monitoring and decision-making brain areas interact so that future behavior may change. By taking advantage of natural variation in error salience, as measured by the RT taken to correct an error (RTEC), here we argue that an evidence ...

Errors generate typical brain responses, characterized by two successive event-related potentials (ERP) following incorrect action: the error-related negativity (ERN) and the positivity error (Pe). However, it is unclear whether these error-related responses are sensitive to the magnitude of the error, or instead show all-or-none effects. We studied error-monitoring with ERPs while healthy adul...

Twisted rapid passage is a type of non-adiabatic rapid passage that gives rise to controllable quantum interference effects that were first observed experimentally in 2003. We show that twisted rapid passage sweeps can be used to implement a universal set of quantum gates that operate with high-fidelity. For each gate in the universal set, sweep parameter values are provided which simulations i...

BACKGROUND Measurements of maximal voluntary inspiratory (PI(max)) and expiratory (PE(max)) pressures are used in the management of respiratory muscle disease. There is little data on the appropriate reference range, success rates, or repeatability of PI(max) and PE(max) in children or on methodological factors affecting test outcomes. OBJECTIVES To determine PI(max) and PE(max) in healthy ch...

BACKGROUND Patients with COPD experience episodes of increased inflammation, so-called acute exacerbations of COPD (AE-COPD). In 30% of AE-COPD cases, no clear cause is found. Since there is well-known cross talk between inflammation and thrombosis, the objectives of this study were to determine the prevalence, embolus localization, clinical relevance, and clinical markers of pulmonary embolism...

Circulating antibodies to factor VIII (anti-VIII, "inhibitors") occurring in patients with hemophilia neutralize porcine factor VIII less readily than human factor VIII in vitro. Over an 18-mo period, 8 patients with anti-VIII were treated with 45 courses (297 infusions) of polyelectrolyte-fractionated porcine factor VIII concentrate (PE porcine VIII). Where no anti-PE porcine VIII was detectab...