Abstract Platinum-binding peptides have been used for fabrication of complex platinum nanomaterials such as catalysts, metallopharmaceuticals, and electrodes. In this review, we present understanding the mechanisms behind platinum-binding (Pt-binding) applications multifunctional biomaterials. We discuss how surface recognition, roles individual amino acids, arrangement acid sequences interplay...

Cancer Therapy In article number 2300107, Moshi Song, Jun Wang, and colleagues used deep learning to identify functional peptides in the metagenome. cover image full of Chinese elements, center piece is a bamboo scroll, oldest form books that circulated represents coded information microbiome. From scroll book genomic/metagenomic information, important paragraphs or sentences (such as protein –...

Key words cyclization - specialty peptides natural products continuous flow acylammonium

Bioactive peptides showing Angiotensin-I-Converting Enzyme inhibitory (ACEi) activity can control blood pressure. They be produced from various protein sources, including fish gelatin. This article provides a systematic review and meta-analysis on gelatin extraction, conditions of enzymatic hydrolysis, characteristics ACEi peptides, effect hydrolysis procedure peptides. Fish preparation uses so...

Hepatitis C Virus (HCV) encodes two envelope glycoproteins, E1 and E2. Our previous work selected a specific aptamer ZE2, which could bind to E2 with high affinity, with a great potential for developing new molecular probes as an early diagnostic reagents or therapeutic drugs targeting HCV. In this study, the binding sites between E2 and aptamer ZE2 were further explored. E2 was truncated to 15...

hepatitis c virus (hcv) encodes two envelope glycoproteins, e1 and e2. our previous work selected a specific aptamer ze2, which could bind to e2 with high affinity, with a great potential for developing new molecular probes as an early diagnostic reagents or therapeutic drugs targeting hcv. in this study, the binding sites between e2 and aptamer ze2 were further explored. e2 was truncated to 15...

Key words rhodium catalysis - C–H functionalization macrocyclic peptides tryptophan-containing

Abstract Protein engineering has great potential for devising multifunctional recombinant proteins to serve as next-generation protein therapeutics, but it often requires drastic modifications of the parental scaffolds e.g., additional domains at N/C-terminus or replacement a domain by another. A discovery platform system, called RaPID (Random non-standard Peptides Integrated Discovery) enabled...