background peptic ulcer disease is a multifactorial health problem affecting almost all populations worldwide. large scale population-based studies are crucial to understanding its scope and specifications in various nations. we aimed to explore environmental risk factors of peptic ulcer disease in the first population based study in ardabil, northwest iran. methods this study was a part of a l...

O ur understanding of the pathophysiological features of peptic ulcer disease has rapidly evolved during the last century. Early understanding of gastric physiologic characteristics led to logical and time-tested surgical procedures aimed at acid reduction and a lowering of ulcer recurrence rates. A dramatic shift in treatment occurred with the recognition and growing knowledge of Helicobacter ...

Giant duodenal ulcers are extensive ulcers, more than 2.5 cm in diameter, that involve a large portion of the duodenal bulb. These atypical duodenal ulcers create serious problems to the patient and the physician, are frequently complicated by bleeding and penetration, and have a high mortality rate. Most of the reported cases were classified as a severe variant of the common peptic ulcer disea...

Emergency endoscopy was done in 306 patients with acute upper gastrointestinal bleeding. Most of the patients were in the age group 20—39 years. Male to female ratio was 2.3:1. The main causes of bleeding were peptic ulcer (40.1 8%), oesophageal varices (32.4%) and superficial mucosal lesions (13.9%). Causes of bleeding remained obscure in 7.2% cases; dual lesions were seen in 2.94%. Complete f...

BACKGROUND We aimed to elucidate the risk factors and preventive factors associated with chronic low-dose aspirin (L-ASA)-induced gastroduodenal mucosal injury in Japanese patients with arteriosclerotic disease. METHODS This retrospective observational study included 400 L-ASA users who underwent upper gastrointestinal endoscopy. We investigated patients' clinical characteristics, including a...

We read with great interest the article “The need for secondlook endoscopy to prevent delayed bleeding after endoscopic submucosal dissection for gastric neoplasms: a prospective randomized trial” by Kim et al. The study was designed to evaluate whether the second-look endoscopy (SLE) strategy can reduce the delayed bleeding complication in patients who underwent endoscopic submucosal dissectio...

BACKGROUND/AIM Bleeding from peptic ulcers can be effectively and safely treated with endoscopic hemoclips therapy. However, due to certain limiting factors of hemoclips, application of combination with another endoscopic method may give better results. The aim of this study was to examine the efficacy and safety of endoscopic hemoclips therapy and to evaluate potential benefits of this therapy...

Purpose. To explore the effects of SiJunZiTang (SJZT) on central neurotransmitters and the inhibition of HCl hypersecretion, along with the role of the vagus nerve. From this, the effects of SJZT and its constituent ingredients on inhibiting stress-induced peptic ulcers will be determined. Methods. Methods used to determine SJZT's effectiveness included (1) measuring the antipeptic ulcer effect...

BACKGROUND Accuracy of the most frequently used tests for diagnosing Helicobacter pylori infection in patients with upper gastrointestinal bleeding of peptic origin is determined. METHODS Seventy-eight patients with endoscopically-proven upper gastrointestinal bleeding of peptic origin were included. The presence of H. pylori was considered when observed from the histology or, if negative, wh...

BACKGROUND Jianzhong decoction is widely used to treat peptic ulcers; however, due to lack of systematic evaluations, its clinical efficacy remains controversial. We performed meta-analysis to evaluate the efficacy and safety of Jianzhong decoction in treating peptic ulcers. METHODS Studies were systematically retrieved from PubMed, Embase, Cochrane library, China National Knowledge Infrastru...