The purpose of this study is to investigate the histological and hormonal observations in fructose-fed, letrozole-induced polycysticovarian- syndrome (PCOS) rats treated with various doses extract asparagus racemosus (EAR) Steroidal saponin (SAPO). 48 female Wistar albino were divided into 8 groups, including Vehicle Control (VC); PCOS; EAR 400 mg/kg; SAPO 40 PCOS + 200 20 mg/ kg; mg/kg. group ...

BACKGROUND Saponins of several herbs are known to induce apoptosis in many cancer cells. The present study aimed to investigate the growth inhibitory effect of Paris saponin VII (PS VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), on the human cervical cancer cell line Hela and the relative molecular mechanisms. METHODS Hela cells were exposed to different concentr...

Dioscorea hispida (D.hispida) is the most well-known starchy tuber in Malaysia and called 'ubi gadong'. Despite concerns over toxicity effects, the tuber is known to possess therapeutic values due to the presence of bioactive compounds such as saponins. This study was performed to identify the changes in gene expression profiles associated with hepatoxicity in pregnant rat treated with D.hispid...

Abstract Objective To provide the scientific basis for utility of rhizome Trillium govanianum as nutraceutical supplements in managing physiological glycemic levels. Methods The vitro enzyme inhibitory activity extract, fractions, and isolated steroidal saponins from part T. was carried out against ?-amylase, ?-glucosidase, dipeptidyl peptidase IV. molecular interactions, binding score, pharmac...

Saponins are plant based biosurfactants that obtained from a wide variety of species. They surface active glycosides with hydrophobic group, which is commonly triterpenoid or steroidal and saccharide hydrophilic units. Their structures markedly different conventional synthetic surfactants, present interesting challenges in understanding their optimal packing self-assembled such as micelles. Fur...

Steroidal saponins isolated from many plant species belonging to Monocotyledones display potent cytotoxic activity towards many human tumor cells. We examined the cytotoxic effects of crude Paris quadrifolia extract for the first time, testing isolated saponin-rich fractions against four different human cell lines using the [(3-(4,5dimethylthiazol-2-yl)]-2,5-diphenyltetrazolium bromide (MTT) as...