Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling test...

Background: Piroxicam is a non-steroidal anti-inflammatory medication for treating fever, discomfort, and inflammation. In addition, piroxicam inhibits cyclooxygenase lowers prostaglandin synthesis, resulting in analgesic effects. Objectives: This study used Franz diffusion cells made from rat skin primed with sesame, eucalyptus, olive, menthol, clove, sunflower oils. Methods: Control was hydra...

topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. the new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. the adhesive capacity of hydroxypropyl methylcellulose (hpmc) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...