New oxyfluorophosphate glass-based composites which exhibit not only green upconversion under 980 nm pumping but also persistent luminescence (PeL) after being UV charged were successfully prepared using the direct doping method. The are composed of a glass-ceramic with Er 3+ doped CaF 2 crystals and luminescent particles SrAl O 4 :Eu,Dy composition. In standard method, glass melt is quenched f...

Primary effusion lymphoma (PEL) is a human herpes virus 8 (HHV8)-positive large B-cell neoplasm that presents as an effusion with no detectable tumor in individuals with human immunodeficiency virus infection or other immune deficiencies. PEL is an aggressive neoplasm with a poor prognosis. PEL cells show diverse morphologies, ranging from immunoblastic or plasmablastic to anaplastic. The immun...

Risk-benefit assessment is a routine requirement for research ethics committees that review and oversee biomedical research with human subjects. Nevertheless, it remains unclear how to weigh and balance risks to research participants against the social benefits that flow from generating biomedical knowledge. In this article, we address the question of whether there are any reasonable criteria f...

The Pel polysaccharide serves as an intercellular adhesin for the formation and maintenance of biofilms in the opportunistic pathogen Pseudomonas aeruginosa. Pel biosynthesis requires the products of a seven-gene operon, pelA-pelG, all of which are necessary for Pel-dependent biofilm formation and Pel-related phenotypes. One of the genes, pelA, encodes a protein with a predicted polysaccharide ...

Primary effusion lymphoma (PEL) is an aggressive subtype of non-Hodgkin lymphoma characterized by short survival with current therapies, emphasizing the urgent need to develop new therapeutic approaches. Brentuximab vedotin (SGN-35) is an anti-CD30 monoclonal antibody (cAC10) conjugated by a protease-cleavable linker to a microtubule-disrupting agent, monomethyl auristatin E. Brentuximab vedoti...

Primary effusion lymphomas (PELs) represent a unique non-Hodgkin lymphoma that is consistently infected by Kaposi sarcoma herpesvirus (KSHV). PEL cells express high levels of the cell cycle inhibitor p27(KIP1) and yet proliferate actively. KSHV genome encodes a viral cyclin homolog, v-cyclin, which has previously been implicated in down-regulation of p27(KIP1) levels. To address how PEL cells c...

Bacterial extracellular polysaccharides are a key constituent of the extracellular matrix material of biofilms. Pseudomonas aeruginosa is a model organism for biofilm studies and produces three extracellular polysaccharides that have been implicated in biofilm development, alginate, Psl and Pel. Significant work has been conducted on the roles of alginate and Psl in biofilm development, however...

In [2], the authors give a polynomial-time algorithm for deciding for a Boolean dynamical system in which each regulatory function is a monomial whether every limit cycle is a steady state. We show that the corresponding problem is NP-hard if the class of permissible regulatory functions contains the quadratic monotone functions xi ∨ xj and xi∧xj. We also show that the problem is NP-hard if the...

Concentrations of free cyanide and total cyanide in water samples in Bogoso and its surrounding areas in Ghana have been measured in this study. Concentrations of free cyanide and total cyanide were found to be above the maximum permissible discharge limit of effluent from mining companies into natural waters set by Environmental Protection Agency, Ghana (GEPA). A comparison of the results obta...