نتایج جستجو برای: pegylation

تعداد نتایج: 824  

2012
Huansheng Dong Tarek M. Fahmy Su M. Metcalfe Steve L. Morton Xiao Dong Luca Inverardi David B. Adams Wenda Gao Hongjun Wang

Two major hurdles need to be surmounted for cell therapy for diabetes: (i) allo-immune rejection of grafted pancreatic islets, or stem/precursor cell-derived insulin-secreting cells; and (ii) continuing auto-immunity against the diabetogenic endogenous target antigen. Nanotherapeutics offer a novel approach to overcome these problems and here we ask if creation of "stealth" islets encapsulated ...

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2006
N. Chilukuri W. Sun R. Naik P. Tipparaju K. Parikh C. Luo A. Saxena Walter Reed

Previous studies in rodents and non human primates demonstrated that pretreatment of animals with cholinesterases (ChEs), both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), could provide significant protection against behavioral and lethal effects of nerve agent intoxication. Currently, human (Hu) serum BChE is under development as a medical countermeasure against organophosphat...

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Journal: :Cancer research 2003
Xinghua Sun Zhijian Yang Shukuan Li Yuying Tan Nan Zhang Xiaoen Wang Shigeo Yagi Takayuki Yoshioka Akio Takimoto Kenji Mitsushima Akinori Suginaka Eugene P Frenkel Robert M Hoffman

Recombinant methioninase (rMETase) is an enzyme active in preclinical mouse models of human cancer. The efficacy of rMETase is due to depletion of plasma methionine, an amino acid for which tumors generally have an abnormally high methionine requirement. Furthermore, transient methionine depletion results in a markedly increased sensitivity of the tumors to several chemotherapeutic agents. This...

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Journal: :Colloids and surfaces. B, Biointerfaces 2014
Kovashnee Naicker Mario Ariatti Moganavelli Singh

The efficiency of liposome-mediated gene delivery is greatly enhanced by appropriate decoration of vehicles with cell-specific targeting ligands. However, liposome-DNA complexes may still be opsonized in serum thus ablating any advantage gained. A stealth aspect may therefore be conferred on complexes by poly(ethylene glycol) (PEG) grafting. Here, we examined the effect that degree of PEGylatio...

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Journal: :Advanced drug delivery reviews 2008
Steve Brocchini Antony Godwin Sibu Balan Ji-won Choi Mire Zloh Sunil Shaunak

PEGylation is a clinically proven strategy for increasing the therapeutic efficacy of protein-based medicines. Our approach to site-specific PEGylation exploits the thiol selective chemistry of the two cysteine sulfur atoms from an accessible disulfide. It involves two key steps: (1) disulfide reduction to release the two cystine thiols, and (2) bis-alkylation to give a three-carbon bridge to w...

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2014
Wuxiao Ding Hiroyuki Minamikawa Naohiro Kameta Toshimi Shimizu Mitsutoshi Masuda

Application of organic nanotubes (ONTs) into drug nanocarriers ultimately requires validation in live animals. For improving the dispersibility in biological media and in vivo distribution, the outer surface of an ONT was functionalized with polyethylene glycol (PEG) via the coassembly of an ONT-forming lipid with 5-20 mol% of a PEG-tethered lipid analogue (PEG-lipid). Firstly, the effect of PE...

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Journal: :The Biochemical journal 2007
Roberto Iafelice Simone Cristoni Dario Caccia Rosaria Russo Luigi Rossi-Bernardi Kenneth C Lowe Michele Perrella

The 2-iminothiolane reaction with protein amino groups adds a spacer arm ending with a thiol group, which can be further treated with molecules carrying a maleimido ring. This approach is currently used for the preparation of a candidate 'blood substitute' in which human Hb (haemoglobin) is conjugated with long chains of PEG [poly(ethylene glycol)]. To identify the thiolation sites by MS, we ha...

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Journal: :European Journal of Pharmaceutical Sciences 2010

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Journal: :Journal of Cell Communication and Signaling 2018

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Journal: :Beilstein Journal of Organic Chemistry 2014

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  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->