نتایج جستجو برای: pegylated

تعداد نتایج: 6170  

2011
Fa Liu Jung-Eun Park Wen-Jian Qian Dan Lim Martin Gräber Thorsten Berg Michael B. Yaffe Kyung S. Lee Terrence R. Burke

We obtained unanticipated synthetic byproducts from alkylation of the δ(1) nitrogen (N3) of the histidine imidazole ring of the polo-like kinase-1 (Plk1) polo-box domain (PBD)-binding peptide PLHSpT. For the highest-affinity byproduct, bearing a C(6)H(5)(CH(2))(8)- group, a Plk1 PBD cocrystal structure revealed a new binding channel that had previously been occluded. An N-terminal PEGylated ver...

Journal: :Journal of controlled release : official journal of the Controlled Release Society 2003
J H van Steenis E M van Maarseveen F J Verbaan R Verrijk D J A Crommelin G Storm W E Hennink

A folate-poly(ethylene glycol) conjugate capable of covalent coupling to primary amines present at the surface of polyplexes was developed. Coating of poly(dimethylaminomethyl methacrylate (pDMAEMA)-based polyplexes with this folate-pEG conjugate led to a sharp decrease of the zeta-potential, and a small increase in particle size. The size of the particles in isotonic medium did not change mark...

Journal: :Nanotechnology 2010
Raja G Rayavarapu Wilma Petersen Liesbeth Hartsuiker Patrick Chin Hans Janssen Fijs W B van Leeuwen Cees Otto Srirang Manohar Ton G van Leeuwen

We evaluated cellular responses to polymer-treated gold nanorods, which were synthesized using the standard wet-chemistry method that utilizes hexadecyltrimethylammonium bromide (CTAB). The nanorod dispersions were coated with either polystyrene sulfonate (PSS) or polyethylene glycol (PEG). Two sizes of nanorods were tested, with optical responses peaking at 628 and 773 nm. The cells were from ...

2015
Joana A Loureiro Bárbara Gomes Manuel AN Coelho Maria do Carmo Pereira Sandra Rocha

AIM The present study was designed to test the cellular uptake of PEGylated liposomes targeted to transferrin receptor and to α-synuclein by a cell model of the blood-brain barrier (BBB). MATERIALS & METHODS PEGylated immunoliposomes were prepared with anti-transferrin receptor OX26 and anti-α-synuclein LB509 antibodies to overcome the BBB in Parkinson's disease. RESULTS The doubly targeted...

Journal: :Bioconjugate chemistry 2010
Rasmus I Jølck Rolf H Berg Thomas L Andresen

A versatile methodology for efficient synthesis of PEGylated lipopeptides via CuAAC "Click" conjugation between alkyne-bearing solid-supported lipopeptides and azido-functionalized PEGs is described. This new and very robust method offers a unique platform for synthesizing PEGylated lipopeptides with a high level of complexity. These molecules, obtained in a single purification step, are ideall...

Journal: :Chest 2003
Sandra Abi-Nassif Eugene J Mark Robert B Fogel Robert K Hallisey

A 49-year-old man with cirrhosis due to hepatitis C virus developed interstitial pneumonitis documented by surgical lung biopsy specimen evaluation after two weekly doses of pegylated interferon-alpha(2)b in combination with ribavirin. He developed ARDS and died after 26 days of hospitalization from multisystem organ failure. This case suggests that interstitial pulmonary disease can occur with...

Journal: :Science and Technology of Advanced Materials 2019

Journal: :Polymer Science, Series C 2020

Journal: :World journal of gastroenterology 2006
Francesca Lodato Maria-Rosa Tame Antonio Colecchia Chiara Racchini Francesco Azzaroli Antonia D'Errico Silvia Casanova Antonio Pinna Enrico Roda Giuseppe Mazzella

Autoimmune manifestations are common both in patients chronically infected by hepatitis C virus, and in patients transplanted for non-autoimmune diseases. A correlation between interferon based treatment and autoimmune diseases or the development of autoantibodies is well established in non-transplanted patients, but few data are available about transplanted patients. It is unclear whether inte...

Journal: :Organic & biomolecular chemistry 2015
Mathieu André Sophie Besse Jean-Michel Chezal Emmanuelle Mounetou

In the development of our melanoma-selective delivery approach, three preselected conjugates of 5-iodo-2'-deoxyuridine (IUdR) to the ICF01012 melanoma-carrier were radiolabelled with iodine-125, and their in vivo distribution profile was determined. A radioiodination method for the conjugate 1a and its PEGylated derivatives 1b-c was developed via electrophilic iododestannylation in good radioch...

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