Quercetin is a bioflavonoid compound with low water solubility in both foods and the gastrointestinal tract, which limits exploitation of its health-promoting properties. This study aims to formulate solid dispersions (SDs) quercetin hydrophilic polyethylene glycol PEG matrices, using melt-mixing method, improve dissolution antioxidant activity quercetin. Initially, total Gibbs free energy for ...

This study aimed to develop an optimized depot injectable atorvastatin (ATR) biodegradable in situ gel (ISG) system with minimum initial burst using a central composite design. The factors selected were poly (d, l-lactide-co-glycolide) (PLGA) concentration (X1), molecular weight of polyethylene glycol (PEG) (X2), and PEG concentration (X3). The independent variables were the initial burst of AT...

The purpose of the present study was to investigate the effect of polyethylene glycol (PEG) molecular weights (6000, 12000 and 20000) as solid dispersion (SD) carriers on the dissolution behavior of simvastatin. SDs with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), infrared spe...

Abstract Plantago albicans L. (Plantaginaceae) grows in wastelands, slopes, and stony pastures, with dry sun‐exposed soils. Its seeds produce a mucilaginous coat. The main aim of this study was to evaluate intraspecific variation osmotic salinity stress response mucilage production P. seeds. relationships between stress, germination characteristics, expansion were studied eight populations . Se...

The aim of the present work was to improve the solubility and dissolution rate of simvastatin (SIM), a drug used for the treatment of hyperlipidemia. Two systems were used: solid dispersions with PEG 4000 and PEG 6000 prepared using the fusion method in various ratio of 1:1, 1:3, and 1:5 and inclusion complexes with HP-β-cyclodextrin obtained by kneading method in a ratio of 1:1 with drug SIM. ...

BACKGROUND Channel proteins like the engineered FhuA Δ1-159 often cannot insert into thick polymeric membranes due to a mismatch between the hydrophobic surface of the protein and the hydrophobic surface of the polymer membrane. To address this problem usually specific block copolymers are synthesized to facilitate protein insertion. Within this study in a reverse approach we match the protein ...

BACKGROUND AND THE PURPOSE OF THE STUDY The success of any direct-tableting procedure is strongly affected by the quality of the crystals used in the process. Ibuprofen is a poorly compactible drug with a high tendency for capping. In order to use ibuprofen in direct compression formulations, physico-mechanical properties of ibuprofen should be improved considerably. The aim of the present inve...

The incorporation of polyethylene glycol-6000 (PEG) into the culture media of tumor-infiltrated spleen cells (TISpC) and MOPC-315 stimulator tumor cells at a responder to stimulator cell ratio of 30/1 had been shown to lead to the appearance of CD8+ T-cells that were effective in adoptive chemoimmunotherapy (ACIT) of mice bearing a barely palpable MOPC-315 tumor (J. A. Wise, M. B. Mokyr, and S....