Two hundred fifty pediatric (less than 18 years of age) patients underwent orthotopic liver transplantation because of end-stage liver disease and were given combination therapy with cyclosporine and prednisone. The most common indications for transplantation in decreasing order of frequency were biliary atresia, inborn errors of metabolism, and postnecrotic cirrhosis. The 5-year actuarial surv...

Hepatoblastoma is the most common pediatric liver tumor and is usually diagnosed before five years of age. Treatment consists of a combination of chemotherapy and surgery, with the goal being attainment of complete local control by surgical resection and eradication of any extrahepatic disease. Neoadjuvant chemotherapy is utilized and is often beneficial in rendering tumors resectable; however,...

61 Received September 11, 2014; revised and accepted January 5, 2015. Published online January 17, 2015; doi: 10.1620/tjem.235.61. Correspondence: Atsushi Fujio, M.D., Ph.D., Division of Transplantation, Reconstruction, and Endoscopic Surgery, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-0872, Japan. e-mail: [email protected] Long-Term Survival with Grow...

The science of kidney transplantation in children has advanced remarkably in the last 40 years [1, 2]. As kidney transplants in adult recipients were becoming more common with improving shortand long-term outcomes, results in children were lagging behind. This lag was attributed to multiple factors: greater surgical and technical problems in small children, different metabolism for needed drugs...

Solid organ transplantation has transformed the lives of many children and adults by providing treatment for patients with organ failure who would have otherwise succumbed to their disease. The first successful transplant in 1954 was a kidney transplant between identical twins, which circumvented the problem of rejection from MHC incompatibility. Further progress in solid organ transplantation ...

We aimed to analyze characteristics of encephalopathy after both hematopoietic stem cell and solid organ pediatric transplantation. We retrospectively reviewed medical records of 662 pediatric transplant recipients (201 with liver transplantation [LT], 55 with heart transplantation [HT], and 67 with kidney transplantation [KT], 339 with allogeneic hematopoietic stem cell transplantation [HSCT])...

BACKGROUND Thalassemia major and its treatment by stem cell transplantation can have deleterious effects on bone integrity. This study assesses the adverse effects of transplantation on growing bones of pediatric thalassemic patients. METHODS Bone mineral density (BMD) of 20 patients from three thalassemia classes whose mean (SD) age was 7.4 (3.8) years were tested with a Norland XR-46 device...

Solid organ transplantation is now routinely performed at many institutions. Pediatric organ recipients present difficult challenges to pediatric anesthesiologists. Physiologic, anatomic, and pharmacologic derangements in this population may make both the surgical procedure and the anesthetic management complicated. This article presents an overview of the unique problems and the strategies to ...

Monica Lodi *, Erika Rebessi , Eliana Parente , Elisa Micalizzi , Maurizio Viri , Donatella Milani , Antonino Romeo a a Pediatric Neurology Unit and Epilepsy Center, Department of Neuroscience, ‘‘Fatebenefratelli e Oftalmico’’ Hospital, Milano, Italy b Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, University of Milan Fondazione IRCCS Ca’ Granda, Ospeda...

Though robust clinical data are available within transplantation, these data are not used for broad-based, multicentered quality improvement initiates. This article describes a targeted quality improvement initiative within the Studies of Pediatric Liver Transplantation (SPLIT) Registry. Using standard statistical techniques and clinical expertise to adjust for data and statistical reliability,...