Animal models are needed to assess novel proteins produced through biotechnology for potential dietary allergenicity. Currently proposed rodent models evaluate sensitizing potential of food extracts or proteins following parenteral administration or oral administration with adjuvant. However, food allergy requires not only the potential to induce immunoglobulin (Ig) E but also the capacity to a...

BackgroundPeanut allergy is the most common food among children. Studies assessing burden of peanut in a real-world setting are limited.ObjectiveTo estimate annual incidence and prevalence cases children aged 4 to 17 years assess severe reaction associated health care utilization rates.MethodsPatient longitudinal data between January 2011 December 2017 from geographically payer-type representat...

BACKGROUND Peanut allergy is a life-threatening condition; there is currently no cure. While whole allergen extracts are used for specific immunotherapy for many allergies, they can cause severe reactions and even fatalities in peanut allergy. OBJECTIVE To identify short, HLA-degenerate CD4(+) T cell epitope-based peptides of the major peanut allergen Ara h 1 that target allergen-specific T c...

wo of the three patients described here were atopic and thus had an increased propensity to develop food allergy, although one of them had no previous food allergies and the third had no previous allergies at all. None was allergic to peanut. None had exercised after eating the implicated foods, and none reacted to normal bread, other wheat sources, or pea. Discussion IgE-mediated food allergy ...

Food allergy affects approximately 5% of children and is the leading cause of hospitalization for anaphylactic reactions in westernized countries. However, the pathways of anaphylaxis in food allergy are still relatively unknown. We investigated the effector pathways of allergic and anaphylactic responses of different strains of mice in a clinical relevant model of peanut allergy. C3H/HeOuJ, C5...

Background Peanut butter is known as a healthy food . It is a type one hypersensitivity reaction to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of children may lead to severe physical symptoms. Peanut allergy is one of the most common causes of anaphylaxis, a pediatrics medical emergency that requires treatment with an epinephrine (ad...

Background Specific IgE to Ara h 2 as clinical predictor for peanut allergy in children has a diagnostic value comparable to a recently published prediction model containing gender, skin prick test (SPT), specific IgE (sIgE) to peanut extract and total IgE. The need for food challenges could be reduced by implicating both methods. In adults, the diagnostic value of peanut components has not bee...

Results 44 peanut allergic children (median age 5 years) reacted to peanut on DBPCPC with clinical symptoms than ranged from oral allergy syndrome to anaphylaxis. 61% of patients reacted to 0.1g of peanut protein. The mean %CD63+ basophil at 10 and 100 ng/ml of PE was independently associated with severity (p=0.012) whilst CD-sens (1/EC50x100) was independently associated with threshold (p=0.03...

OBJECTIVE The goal was to determine whether patients seen in a referral clinic are experiencing initial allergic reactions to peanuts earlier, compared with a similar population profiled at a different medical center 10 years ago, and to investigate other changes in clinical characteristics of the patients between the 2 groups. METHODS We reviewed the medical charts of peanut-allergic patient...

The clinical role of Ara h 6 sensitization in peanut allergy is a current matter of debate. We investigated the role of Ara h 6 sensitization patterns in a sample of young adults from different Italian cities. Sera of 33 patients with specific IgE against Ara h 6 were selected. According to clinical symptoms upon peanut ingestion, patients were divided into severe reaction (SR) and mild-toleran...