نتایج جستجو برای: pdgfr β

تعداد نتایج: 178428  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Halldora K Thorarinsdottir Mariarita Santi Robert McCarter Elisabeth J Rushing Robert Cornelison Alessandra Jales Tobey J MacDonald

PURPOSE We previously showed that overexpression of epidermal growth factor receptor (EGFR) is associated with malignant grade in childhood glioma. The objective of this study was to determine whether protein expression of EGFR or platelet-derived growth factor receptor (PDGFR) and their active signaling pathways are related to malignant histology, progression of disease, and worse survival. ...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2015
Martin J J Ronis Kelly E Mercer Brenda Gannon Bridgette Engi Piotr Zimniak Colin T Shearn David J Orlicky Emanuele Albano Thomas M Badger Dennis R Petersen

To test the significance of lipid peroxidation in the development of alcoholic liver injury, an ethanol (EtOH) liquid diet was fed to male 129/SvJ mice (wild-type, WT) and glutathione S-transferase A4-4-null (GSTA4-/-) mice for 40 days. GSTA4-/- mice were crossed with peroxisome proliferator-activated receptor-α-null mice (PPAR-α-/-), and the effects of EtOH in the resulting double knockout (dK...

Journal: :Molecular cancer therapeutics 2016
Alessia Calgani Giulia Vignaroli Claudio Zamperini Federica Coniglio Claudio Festuccia Ernesto Di Cesare Giovanni Luca Gravina Claudia Mattei Flora Vitale Silvia Schenone Maurizio Botta Adriano Angelucci

Glioblastoma cells efficiently interact with and infiltrate the surrounding normal tissue, rendering surgical resection and adjuvant chemo/radiotherapy ineffective. New therapeutic targets, able to interfere with glioblastoma's capacity to synergize with normal brain tissue, are currently under investigation. The compound Si306, a pyrazolo[3,4-d]pyrimidine derivative, selected for its favorable...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004
Linnea M Baudhuin Ying Jiang Alexander Zaslavsky Isao Ishii Jerold Chun Yan Xu

Akt plays a pivotal role in cell survival and tumorigenesis. We investigated the potential interaction between sphingosine-1-phosphate (S1P) and platelet-derived growth factor (PDGF) in the Akt signaling pathway. Using mouse embryonic fibroblasts (MEFs) from S1P receptor knockout mice, we show here that S1P3 was required for S473 phosphorylation of Akt by S1P. In addition, S1P-stimulated activa...

2015
Haeyeong Lee Byoung H. Koh Evan Yamasaki Nikita E. George Kenton M. Sanders Sang Don Koh

Lee H, Koh BH, Yamasaki E, George NE, Sanders KM, Koh SD. UTP activates small-conductance Ca -activated K channels in murine detrusor PDGFR cells. Am J Physiol Renal Physiol 309: F569–F574, 2015. First published July 22, 2015; doi:10.1152/ajprenal.00156.2015.— Purines induce transient contraction and prolonged relaxation of detrusor muscles. Transient contraction is likely due to activation of ...

Journal: :Dermatology 2008
A Soria M Cario-André S Lepreux H R Rezvani J M Pasquet C Pain T Schaeverbeke F X Mahon A Taïeb

BACKGROUND Scleroderma skin overexpresses the platelet-derived growth factor receptor beta-subunit (PDGFR-beta) in dermal vessels and PDGFR-beta messenger RNA in cultured fibroblasts. Moreover, increased levels of PDGF and stimulatory autoantibodies to PDGFR have been identified in the serum of scleroderma patients. OBJECTIVE Imatinib being an inhibitor of tyrosine kinase receptors such as PD...

Journal: :Development 2000
L Karlsson P Lindahl J K Heath C Betsholtz

Development of the gastrointestinal (GI) tract depends on reciprocal epithelial-mesenchymal cell signaling. Here, we demonstrate a role for platelet-derived growth factor-A (PDGF-A) and its receptor, PDGFR-(alpha), in this process. Mice lacking PDGF-A or PDGFR-(alpha) were found to develop an abnormal GI mucosal lining, including fewer and misshapen villi and loss of pericryptal mesenchyme. Ons...

2017
Yiquan Wu Adrian Prager Simone Boos Moritz Resch Ilija Brizic Michael Mach Sabrina Wildner Laura Scrivano Barbara Adler

Herpesvirus gH/gL envelope glycoprotein complexes are key players in virus entry as ligands for host cell receptors and by promoting fusion of viral envelopes with cellular membranes. Human cytomegalovirus (HCMV) has two alternative gH/gL complexes, gH/gL/gO and gH/gL/UL128,130,131A which both shape the HCMV tropism. By studying binding of HCMV particles to fibroblasts, we could for the first t...

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