objective(s) two new adjuvants from natural animal lipids (g2) and bacterial polysaccharide extracts (pc) were previously prepared by our group and showed a reduction in tracheal responsiveness. the aim of this study was to evaluate the preventive effect of recently introduced natural products (g2 and pc) on the development of asthma. materials and methods asthma was induced using a standard me...

The lipophilic anthracycline antibiotic annamycin (Ann) was entrapped in liposomes of different size [median diameter: 1.64 microns, multilamellar liposomal Ann (L-Ann); 0.030 micron, small unilamellar Ann (S-Ann)] with > 90% entrapment efficiency and tested in vitro against four pairs of sensitive and multidrug-resistant (MDR) tumor cell lines and in vivo by the i.v. route in five tumor models...

Departments of Internal Medicine and Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, USA Ann Arbor Veterans Affairs Healthcare System, and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States Ann Arbor Veterans Affairs Healthcare System, Ann Arbor, Michigan, USA Departments of Internal Medicine and Learning Health Science...

The release of molecules from injured tissue leads to produce inflammatory response that can result in apoptosis and cell death. Preconditioning (PC) can decrease the inflammatory response, increase neuroprotective mechanism on different levels. So, we investigated the role of PC as a suitable preventative approach in neurodegenerative disease in and inflammatory oncogenic factors in PC12 cells...