Ras and Rho small GTPases possessing a C-terminal polybasic region (PBR) are vital signaling proteins whose misregulation can lead to cancer. Signaling by these proteins depends on their ability to bind guanine nucleotides and their prenylation with a geranylgeranyl or farnesyl isoprenoid moiety and subsequent trafficking to cellular membranes. There is little previous evidence that cellular si...

Anemia may worsen neurological outcomes following traumatic brain injury (TBI) by undefined mechanisms. We hypothesized that hemodilutional anemia accentuates hypoxic cerebral injury following TBI. Anesthetized rats underwent unilateral TBI or sham injury (n > or = 7). Target hemoglobin concentrations between 50 and 70 g/l were achieved by exchanging 40-50% of the blood volume (1:1) with pentas...

In this paper I review a new Research-based methodology (Robinson 1996) to find an overarching theoretical framework for my MPhil dissertation (Punia 1992). I first review my MPhil (Punia 1992). A review of the new methodology to test its suitability to provide an overarching theory for my MPhil dissertation follows next. The new methodology presents a form of action research from the perspecti...

The human brain is continually, dynamically active and spontaneous fluctuations in this activity play a functional role in affecting both behavioural and neuronal responses. However, the mechanisms through which this occurs remain poorly understood. Simultaneous EEG-fMRI is a promising technique to study how spontaneous activity modulates the brain's response to stimulation, as temporal indices...

The small GTPase RhoA has been implicated in various cellular activities, including the formation of stress fibers, cell motility, and cytokinesis. In addition to the canonical GTPase cycle, recent findings have suggested that phosphorylation further contributes to the tight regulation of Rho GTPases. Indeed, RhoA is phosphorylated on serine 188 (188S) by a number of protein kinases. We have re...

OBJECTIVE To explore the histological, electrophysiological, radiological, and behavioral effects of radiosurgery using a new model of proton beam radiosurgery (PBR) of the rodent hippocampus. METHODS Forty-one rats underwent PBR of the right hippocampus with nominal doses of 5 to 130 cobalt Gray equivalents (CGE). Three control animals were untreated. Three months after PBR, 41 animals were ...

With the rapid development of virtual reality (VR) technology, digital materials have become more realistic and controllable, offering new opportunities for material perception research. However, parameters physically based rendering (PBR), which are widely used in industry, often derived from design experience lack interpretability. This study aims to investigate visual difference glossiness b...

The Global Navigation Satellite System (GNSS)-based passive bistatic radar (PBR) which uses the GNSS signal as illuminators of opportunity is studied for moving target detection (MTD). GNSS-based PBR has many advantages due to removal transmitting device; however, its fundamental limitation low power density signal. Therefore, integration time should be sufficiently long obtain a promising maxi...

This article presents an investigation on the recovery of CO2 from combustion gases cement industry through a carbonation route in order to obtain Calcium Carbonate Nanoparticles (CCnP), which could find application as either polymer or fillers. Two different experimental setups, Continuously Stirred Bubbling Reactor (CSBR) and Packed Bed (PBR), were studied improve final product enhance proces...

In this article a comprehensive set of registration methods is utilized to provide image-to-physical space registration for image-guided neurosurgery in a clinical study. Central to all methods is the use of textured point clouds as provided by laser range scanning technology. The objective is to perform a systematic comparison of registration methods that include both extracranial (skin marker...