نتایج جستجو برای: pbo
تعداد نتایج: 1409 فیلتر نتایج به سال:
ML-3 and -7 demonstrated a significant OS benefit maintenance/improvement of QOL with RIB + ET vs in pts HR+/HER2? ABC. We evaluated the association -7. In ML-3, postmenopausal were treated fulvestrant (FUL) or FUL alone. This analysis included NSAI cohort ML-7, which peri/premenopausal was assessed EORTC QLQ-C30. A responder performed based on published minimal clinically important differences...
Aedes (Stegomyia) aegypti (L.) and Aedes (Stegomyia) albopictus (Skuse) larvae rely on oxidases to reduce toxicity of water soluble toxins from some senescent tree leaf infusions. The mortality of third instar Ae. aegypti larvae in live oak and pin oak leaf infusions increased significantly in the presence of piperonyl butoxide (PBO), a broad inhibitor of cytochrome P450s (CYPs). In contrast, P...
Future power systems are expected to have distributed energy resources (DERs). A price-based operation (PBO), where dynamic prices are used as the control signal, can be an alternative scheme to address challenging operational issues in the future power systems. In this paper, a decentralized framework for optimal PBO using a feedback control mechanism is proposed to determine the nodal prices ...
OBJECTIVE The impact of childhood trauma was examined in 427 adolescents (54% girls, 74% Caucasian, mean = 14.6, SD = 1.5) with major depressive disorder participating in the Treatment for Adolescents with Depression Study (TADS). METHOD TADS compared the efficacy of cognitive behavioral therapy (CBT), fluoxetine (FLX), their combination (COMB), and placebo (PBO). Teens were separated into fo...
Insects have long been known to excrete toxins via the Malpighian (renal) tubules. In addition, exposure to natural or synthetic toxins is commonly associated with increases in the activity of detoxification enzymes such as the P450 monoxygenases (P450s) and the glutathione-S-transferases (GSTs). We examined the links between mechanisms for detoxification and excretion in adult Drosophila melan...
Methods This is a phase 3, multicenter, randomized, double-blind (DB) study in patients (pts) aged ≥6 to <18 years (yr) with ERA (ILAR criteria) with active disease not responsive to ≥1 nonsteroidal anti-inflammatory drug and ≥1 disease-modifying antirheumatic drug. Active disease was defined as ≥3 active joints (swelling or loss of motion + pain/tenderness) and enthesitis in ≥1 location. Pts w...
Background Combination of selumetinib plus docetaxel provided clinical benefit in a previous phase II trial for patients with KRAS-mutant advanced non-small-cell lung cancer (NSCLC). The phase II SELECT-2 trial investigated safety and efficacy of selumetinib plus docetaxel for patients with advanced or metastatic NSCLC. Patients and methods Patients who had disease progression after first-lin...
Carboplatin-paclitaxel (CP) is standard of care (SOC) for first-line treatment primary A/R EC; median OS <3 yrs. Use anti–PD-1s with chemo has improved outcomes in multiple tumour types. RUBY (NCT03981796) evaluated the efficacy and safety anti–PD-1 dostarlimab (D)+CP EC compared CP alone. a phase III, global, randomised, double-blind, multicentre, PBO-controlled study. Pts advanced stage III o...
Most healthy children shrug off viral respiratory tract infections with little difficulty or assistance and a full recovery is the norm. A small minority, in contrast, are left with serious consequences. Important among these is postinfectious bronchiolitis obliterans (pBO) characterised by persistent—and sometimes severe—airway obstruction with functional and radiological evidence of small air...
OBJECTIVE To compare the rates of physical, psychiatric, and suicide-related events in adolescents with MDD treated with fluoxetine alone (FLX), cognitive-behavioral therapy (CBT), combination treatment (COMB), or placebo (PBO). METHOD Safety assessments included adverse events (AEs) collected by spontaneous report, as well as systematic measures for specific physical and psychiatric symptoms...
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