Different types of Artemisia aucheri extracts were reported to have various biological activities including a cytotoxic effect on some cancer cell lines. We investigated the antiproliferative activity of isolated sesquiterpenoids from petroleum ether extract of Artemisia aucheri (A. aucheri)aerial parts on SK-N-MC, MCF-7, and A2780 cell lines. Phytochemicals from the petroleum ether cold macera...

Proof: We only need to show one direction, since the inverse element σ−1 is also a symmetry. Let π = o1 · . . . · ok be a plan for s and let s0, . . . , sk be the sequence of states such that s0 = s and for 1 ≤ i ≤ k, si = si−1JoiK. Let TΠ = 〈S,E〉. Then we have 〈si−1, si; oi〉 ∈ E for all 1 ≤ i ≤ k and therefore, by the definition of symmetries we have 〈σ(si−1), σ(si);σ(oi)〉 ∈ E and C(σ(oi)) = C...

Calculating the \soft inverse" of a deterministic nite-state machine (FSM) via the SISO (soft-in/soft-out) module is a key operation in many data detection/decoding algorithms [1, 3]. Perhaps the most appreciated application is iterative decoding of concatenated codes. The standard SISO algorithm is the forward-backward algorithm (e.g., [1, 3]) which can be derived from the generalized distribu...

The mammalian protease plasminogen can be activated by bacterial activators, the three-domain (alpha, beta, gamma) streptokinases and the one-domain (alpha) staphylokinases. These activators act as plasmin(ogen) cofactors, and the resulting complexes initiate proteolytic activity of host plasminogen which facilitates bacterial colonization of the host organism. We have investigated the kinetic ...

where U = V k−mV k−m+1 · · ·V k−1. For the L-BFGS, we need not explicitly store the approximated inverse Hessian matrix. Instead, we only require matrix-vector multiplications at each iteration, which can be implemented by a twoloop recursion with a time complexity of O(mn) (Jorge & Stephen, 1999). Thus, we only store 2m vectors of length n: sk−1, sk−2, · · · , sk−m and yk−1,yk−2, · · · ,yk−m w...

Phosphoinositide-3 kinase (PI-3 kinase) and its downstream signaling molecules PDK-1 and Akt were analyzed in SK-N-SH and SK-N-BE(2) human neuroblastoma cell lines. When cells were stimulated with insulin, PI-3 kinase was activated in both cell lines, whereas the translocation of PDK-1 to the membrane fraction and phosphorylated Akt were observed only in SK-N-SH cells. Analyses of the insulin-m...

The role of the streptokinase (SK) alpha-domain in plasminogen (Pg) and plasmin (Pm) interactions was investigated in quantitative binding studies employing active site fluorescein-labeled [Glu]Pg, [Lys]Pg, and [Lys]Pm, and the SK truncation mutants, SK-(55-414), SK-(70-414), and SK-(152-414). Lysine binding site (LBS)-dependent and -independent binding were resolved from the effects of the lys...

Wilms tumor (WT) is the most common pediatric malignant primary renal tumor. Carboplatin (CRB), a platinum compound is widely used in the treatment of multiple cancers including ovarian, lung, head and neck, and wilm’s tumor. However lower uptake of CRB in cancer cells and toxicity concerns in healthy cells often limited its clinical outcome. The aim of this study was to investigate the antitum...

An identifying code in a graph G is a subset of vertices with the property that for each vertex v ∈ V (G), the collection of elements of C at distance at most 1 from v is non-empty and distinct from the collection of any other vertex. We consider the minimum density d(Sk) of an identifying code in the square grid Sk of height k (i.e. with vertex set Z × {1, . . . , k}). Using the Discharging Me...

BACKGROUND Phosphorylation of sphingosine by sphingosine kinase (SK) is the rate-limiting step in the cellular synthesis of sphingosine 1-phosphate (S1P). The monoganglioside GM1, which stimulates SK, is cardioprotective in part through increased generation of S1P that protects myocytes by diverse mechanisms. Because protein kinase C (PKC)epsilon activation is necessary for myocardial ischemic ...