Pyrrolobenzodiazepines (PBDs) are sequence-selective DNA minor-groove binding agents that covalently bond to guanine with a reported preference for Pu-G-Pu sequences (Pu = Purine). Using HPLC/MS and Circular Dichroism (CD) methodologies, we have established for the first time that the aminal bond formed between PBD molecules and DNA is reversible. Furthermore, we have shown that while the rate ...

Sensorineural deafness and retinitis pigmentosa (RP) are the hallmarks of Usher syndrome (USH) but are also prominent features in peroxisomal biogenesis defects (PBDs); both are autosomal recessively inherited. The firstborn son of unrelated parents, who both had sensorineural deafness and RP diagnosed as USH, presented with sensorineural deafness, RP, dysmorphism, developmental delay, hepatome...

We develop a scalable cell-level analytical model for multi-cell infrastructure IEEE 802.11 WLANs under a so-called Pairwise Binary Dependence (PBD) condition. The PBD condition is a geometric property under which the relative locations of the nodes inside a cell do not matter and the network is free of hidden nodes. For the cases of saturated nodes and TCP-controlled long-file downloads, we pr...

The spatial distribution of species, functional traits and phylogenetic relationships at both the regional and local scales provide complementary approaches to study patterns of biodiversity and help to untangle the mechanisms driving community assembly. Few studies have simultaneously considered the taxonomic (TBD), functional (FBD) and phylogenetic (PBD) facets of beta diversity. Here we anal...

An computer-aided diagnosis system of pathological brain detection (PBD) is important for help physicians interpret and analyze medical images. We proposed a novel automatic PBD to distinguish pathological brains from healthy brains in magnetic resonance imaging scanning in this paper. The proposed method simplified the PBD problem to a binary classification task. We extracted the wavelet packe...

E-Delta 2-valproic acid (E-Delta 2-VPA), a major active metabolite of VPA, has been proposed as an alternative to VPA because it is less hepatotoxic and is nonteratogenic. In rodents, VPA and E-Delta 2-VPA have a brain tissue/free plasma concentration ratio less than unity, which suggests rapid removal of the alkanoate anticonvulsants from the central nervous system. This study in rabbits emplo...

A critical overview of the extensive literature on fluctuations in the DNA double helix is presented. Both theory and experiment are comprehensively reviewed and analyzed. Fluctuations, which open up the DNA double helix making bases accessible for hydrogen exchange and chemical modification, are the main focus of the review. Theoretical descriptions of the DNA fluctuations are discussed with s...

In this paper, we look at resolvable balanced incomplete block designs on v points having blocks of size 4, briefly (v, 4, 1) RBIBDs. The problem we investigate is the existence of (v, 4, 1) RBIBDs containing a (w, 4, 1) RBIBD as a subdesign. We also require that each parallel class of the subdesign should be in a single parallel class of the containing design. Removing the subdesign gives an i...