Wnt signaling pathways in vertebrates use the phosphoprotein Dishevelled (Dvl). The cellular responses to Wnt signaling may in part be modulated by Dvl-associated proteins, including Dapper (Dpr). We have cloned and characterized the zebrafish Dpr paralogs Dpr1 and Dpr2. Loss-of-function studies reveal that endogenous Dpr1 but not Dpr2 is required to enhance Wnt/beta-catenin activity in zebrafi...

DEAR EDITOR, Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP) is a rare subtype of EBS that is characterized by blistering, mottled pigmentation of the trunk and limbs, punctate hyperkeratosis of the palms and soles, and dystrophic nails. EBS-MP is caused by a mutation in the KRT5 or KRT14 gene encoding keratin 5 (K5) and keratin 14 (K14), respectively. Dermatopathia pigmentosa ...

Riset ini bertujuan untuk menganalisis pengaruh debt equity ratio (DER), return on assets (ROA), dan firm size (FS) terhadap dividend payout (DPR) pada perusahaan terbuka yang terdaftar dalam indeks Kompas100 selama periode 2016–2019. Teknik pengambilan sampel riset menggunakan purposive sampling yaitu teknik dengan kriteria sebagai Kompas 100, membagikan dividen secara berturut-turut 2016 – 20...

The dietary crude protein requirement of penaeid shrimp is an important nutritional consideration because protein is often the major limiting nutrient for growth. In most cases, research has focused on total dietary protein levels rather than a daily requirement for protein. This research utilized three practical diets containing 16%, 32%, and 48% protein and various daily rations to estimate d...

BACKGROUND Previous studies have reported that hip abnormalities may account for 10% of injuries in professional football players. The effect of femoroacetabular impingement (FAI) and arthroscopic FAI surgery in National Football League (NFL) athletes has not been well studied. PURPOSE To investigate the effect of arthroscopic FAI surgery on return to play (RTP) and RTP performance in NFL pla...

In order to secure the quality of precipitation estimates, ground validation (GV) of satellite data and retrieval algorithms is essential. Since end-to-end comparisons between instantaneous precipitation data observed by satellite and groundbased instruments is not enough to improve the algorithms. The error of various physical parameters in the precipitation retrieval algorithms (e.g. attenuat...

Meeting future water demand will require serious consideration of direct potable reuse (DPR) for many agencies. There has been tremendous progress in the technologies needed to address concerns that conventional and novel contaminants pose. Yet, date, only a few relatively small DPR operations have installed. As we get closer point where regulations are finalized investments planned, there is n...