202 Isabella is a nine-year-old with Prader-Willi syndrome (PWS), secondary to a paternal interstitial deletion (15q-). Her parents seek your advice on the use of human growth hormone (GH) because despite a program of physical activity and rigorous dietary management with the red-yellow-green weight control system, their daughter’s obesity is increasing . Lately, she is more tired, has headache...

Rejection after allogeneic bone marrow transplantation for Fanconi anemia (FA) is a complication with a high risk of mortality. We describe a patient who, following a second episode of rejection after a second allogeneic stem cell transplantation, was successfully treated with antilymphocyte globulin, followed by donor lymphocyte infusion. At three and a half years after donor lymphocyte infusi...

PURPOSE This study was conducted to compare the paternal rearing behavior and rearing stress level between fathers with a preschooler and fathers with school children so that it can be utilized as a basic source for developing parental rearing education programs. METHODS A descriptive comparative method was conducted to identify the paternal rearing behavior and paternal rearing stress. Respo...

Males and females usually invest asymmetrically in offspring. In species lacking parental care, females influence offspring in many ways, while males only contribute genetic material via their sperm. For this reason, maternal effects have long been considered an important source of phenotypic variation, while paternal effects have been presumed to be absent or negligible. The recent surge of st...

the present research was conducted under laboratory and field condition to determine seed priming effects on maize inbred line's germination, emergence, and grain yield. seeds of two maize inbred lines include of mo17 (as paternal line) and b73 (as maternal line with cytoplasmic sterility) in the laboratory conditions were subjected to hydropriming for 12, 24, 36 and 48 h, or osmoticprimin...

Pharmacological experiments have implicated a role for central arginine vasopressin (AVP) in regulating paternal behavior in monogamous prairie voles. Although nonmonogamous meadow voles exhibit appreciable paternal care when housed under winter, short day lengths (SD), no research has examined whether the same neurobiological systems are involved in regulating paternal behavior in a nonmonogam...

B-lymphocyte depletion therapy is being explored in a wide range of autoimmune disorders. In many, there is early evidence for efficacy, and immunosuppression has not been a major problem. The mechanism of action is unclear, but appears to be consistent with the lowering of autoantibody levels, where relevant antibodies are quantifiable. An interesting finding is the persistence of clinical imp...

OBJECTIVE To determine if paternal age elevates the risk of low birthweight (< 2500g, LBW), preterm birth (< 37 weeks gestation), and multiple gestation among mothers whose age does not predict an elevated risk. DESIGN/METHODS Population data on birth outcome, maternal age and paternal age was obtained from Alberta Health and Wellness for all births 1990-1996. RESULTS Among women aged 25 to...

Mitochondria are inherited maternally in most animals, but the mechanisms of selective paternal mitochondrial elimination (PME) are unknown. While examining fertilization in Caenorhabditis elegans, we observed that paternal mitochondria rapidly lose their inner membrane integrity. CPS-6, a mitochondrial endonuclease G, serves as a paternal mitochondrial factor that is critical for PME. We found...

STUDY QUESTION How has the mean paternal age in the USA changed over the past 4 decades? SUMMARY ANSWER The age at which men are fathering children in the USA has been increasing over time, although it varies by race, geographic region and paternal education level. WHAT IS KNOWN ALREADY While the rise in mean maternal age and its implications for fertility, birth outcomes and public health ...