BACKGROUND Visual hallucinations are commonly seen in various neurological and psychiatric disorders including schizophrenia. Current models of visual processing and studies in diseases including Parkinsons Disease and Lewy Body Dementia propose that Acetylcholine (Ach) plays a pivotal role in our ability to accurately interpret visual stimuli. Depletion of Ach is thought to be associated with ...

Swallowing difficulties and constipation were included in the first description of Parkinsons ́s syndrome from 1817 (Parkinson 1817). Since then, numerous studies have confirmed the magnitude of symptoms and addressed their pathophysiology. In spite of this, much remains to be determined and treatment of gastrointestinal dysfunction in Parkinson ́s disease (PD) is often unsatisfactory. Parkinson ́...

Motivation: A bioinformatics platform is introduced aimed at identifying models of disease-specific pathways, as well as a set of network measures that can quantify changes in terms of global structure or single link disruptions.The approach integrates a network comparison framework with machine learning molecular profiling. The platform includes different tools combined in one Open Source pipe...

D-Serine is an endogenous NMDA receptor co-agonist that activates synaptic NMDA receptors modulating neuronal networks in the cerebral cortex and plays a key role in long-term potentiation of synaptic transmission. D-serine is associated with NMDA receptor neurotoxicity and neurodegeneration and elevated D-serine concentrations have been associated with Alzheimer's and Parkinsons' diseases and ...

Oxidative modifications are the hallmark of oxidative imbalance in the brain of individuals with Alzheimers, Parkinsons and Prion diseases and their respective animal models. The aim of the research was to study the impact of aluminum chloride (AlCl3) administration in drinking water (7mg/kg body weight) and Dgalactose(i.p).The results revealed that the levels of lipidperoxidation were signific...

OBJECTIVE Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment of choice for patients with advanced idiopathic Parkinson's disease (PD) who have motor complication with medication. The objectives of this study are to analyze long-term follow-up data of STN DBS cases and to identify the factors related to outcomes. METHODS Fifty-two PD patients who underwent STN DBS...