نتایج جستجو برای: parkinsonian disorders
تعداد نتایج: 672582 فیلتر نتایج به سال:
Parkinson's disease (PD) is the second common neurodegenerative disease. Identification of biomarkers for early diagnosis and prediction of disease progression is important. The present comparative proteomic study of serum samples using two-dimensional fluorescence differential gel electrophoresis followed by ELISA confirmation demonstrated that protein expression of Rab35 was increased in PD p...
Background: Parkinson's disease (PD) and atypical parkinsonian disorders (APD) [multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD)] are a large group of idiopathic neurological diseases, together affecting millions of patients worldwide. Huntington's disease (HD) is a rare autosomal dominant neurological disorder with an overall prevalence o...
BACKGROUND AND PURPOSE Mild motor symptoms including parkinsonian signs are common in old age, but their underlying neuropathology is unclear. We tested the hypothesis that cerebrovascular pathologies are related to parkinsonian signs. METHODS We studied brain autopsies from 418 deceased participants from the Religious Order Study, who underwent evaluation of parkinsonian signs with a modifie...
Tremor is a cardinal feature of Parkinson's disease and essential tremor, the two most common movement disorders. Yet, the mechanisms underlying tremor generation remain largely unknown. We hypothesized that driving deep brain stimulation electrodes at a frequency closely matching the patient's own tremor frequency should interact with neural activity responsible for tremor, and that the effect...
Pain is a frequent, but poorly studied symptom of Parkinson's disease (PD). DoPaMiP survey aimed to assess the prevalence of chronic pain in PD, to describe PD patients with chronic pain, and to record analgesic consumption. About 450 parkinsonian patients underwent structured standardized clinical examination and completed self-reported questionnaires in a cross sectional survey. Pains related...
Two patients who had suffered severe carbon monoxide intoxication showed lasting neuropsychologic sequelae: 1) deep inertia involving the whole behaviour and expressed by an almost complete lack of activity if not induced by someone else; a mental gap when the patients were left to themselves and a tendency to give up the mental activity when stimuli ceased; an apparent affective indifference c...
Background: Clinical diagnosis of multiple system atrophy (MSA) relays on signs and symptoms that are often difficult to identify particularly at early stage. Indeed neuropathological studies have demonstrated that Parkinson variant of MSA (MSA-P) is the first cause of misdiagnosis in a cohort of patients presenting with parkinsonian features. But accurate diagnosis of these disorders is import...
BACKGROUND Pain is a common nonmotor symptom in Parkinson's disease (PD). The pathophysiology of pain in PD is not well understood. Pain characteristics have rarely been studied in atypical parkinsonian disorders such as Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP). AIM OF THE STUDY We aimed to evaluate pain intensity, location, and associated symptoms in atypical pa...
Movement disorders commonly are associated with many psychotropic drugs. Tricyclic antidepressants often cause a tremor in the hands and myoclonic jerks. In some patients, they result in agitation and restlessness, referred to as the jitteriness syndrome [1]. Occasional anecdotes of dyskinesia and dystonia have been reported with these drugs, but tardive dyskinesia typically is not associated w...
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