Within the base excision repair (BER) pathway, the DNA N-glycosylases are responsible for locating and removing the majority of oxidative base damages. Endonuclease III (Nth), formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) are members of two glycosylase families: the helix-hairpin-helix (HhH) superfamily and the Fpg/Nei family. The search mechanisms employed by these two ...

whose revenues continue to increase, the society remains in outstanding financial health. Society membership increased during FY 2012: membership-only subscriptions increased from 456 in 2011 to 732 in 2012, while society membership + journal subscriptions increased from 239 in 2011 to 313 in 2012. The society used its income to publish its two journals, MBE and GBE, and to support its annual m...

Nucellar embryony (NE) is an adventitious form of apomixis common in citrus, wherein asexual embryos initiate directly from nucellar cells surrounding the embryo sac. NE enables the fixation of desirable agronomic traits and the production of clonal offspring of virus-free rootstock, but impedes progress in hybrid breeding. In spite of the great importance of NE in citrus breeding and commercia...

Postsegregational killing (PSK) systems consist of a tightly linked toxin-antitoxin pair. Antitoxin must be continually produced to prevent the longer lived toxin from killing the cell. PSK systems on plasmids are widely believed to benefit the plasmid by ensuring its stable vertical inheritance. However, experimental tests of this "stability" hypothesis were not consistent with its predictions...

A UNA RIFLESSIONE TEORICA FONDANTE RIFERITA AL TERMINE IXD, E NON AVREBBE TUTTI I TORTI. QUELLO DI FAR EVOLVERE LE COSE NATURALMENTE È UN ATTEGGIAMENTO MOLTO PRAGMATICO, DI ESTREMA EFFICACIA QUANDO SI HA A CHE FARE CON L'EMERGERE DI UN NUOVO SETTORE. OGGI PERÒ L'IXD PUÒ CONTARE SU UNA DISCRETA FIDELIZZAZIONE, SU ALCUNE SCUOLE DI FORMAZIONE E SULL'APPORTO DI "ADEPTI" PROVENIENTI DA NUMEROSE DISC...

DNA glycosylases from the Fpg/Nei structural superfamily are base excision repair enzymes involved in the removal of a wide variety of mutagen and potentially lethal oxidized purines and pyrimidines. Although involved in genome stability, the recent discovery of synthetic lethal relationships between DNA glycosylases and other pathways highlights the potential of DNA glycosylase inhibitors for ...

The Association for Research in Vision (ARVO), together with the Foundation Fighting Blindness (FFB), organized the National Eye Institute (NEI)–Food and Drug Administration (FDA) endpoints workshop on age-related macular degeneration (AMD) and inherited retinal diseases (IRD) on November 9, 2016. The public workshop convened basic researchers, clinicians, and regulatory authorities in an inter...

PURPOSE To assess the psychometric properties of the National Eye Institute Refractive Error Quality of Life (NEI-RQL-42) questionnaire in keratoconus and compare these findings to patients with refractive error correction alone. METHODS The Portuguese version of the NEI-RQL-42 Quality of Life questionnaire was completed by 44 patients who had keratoconus before and after implantation of intr...

This paper presents the first National Emissions Inventory (NEI) of fine particulate matter (PM2.5) that includes the full suite of PM2.5 trace elements (atomic number > 10) measured at ambient monitoring sites across the U.S. PM2.5 emissions in the NEI were organized and aggregated into a set of 84 source categories for which chemical speciation profiles are available (e.g., Unpaved Road Dust ...

The contribution of the ‘new economy’ to economic growth in developing countries has so far been minimal. Despite the recent hype, the ‘old economy’ will for long be the fundamental force behind economic growth in transition economies. Nonetheless, in the longer run the ‘new economy’ offers great potential for faster economic growth in postsocialist economies. Realizing this potential is howeve...