We investigated the in vivo activity of crude water extracts of Ajuga remota Benth (Labiatae) against Plasmodium berghei in mice using plants harvested from two areas in Kenya where the plant is commonly used to treat malaria. The extract was tested using a 4-day test at a dose of 30 mg/kg/day (equivalent to 0.2 ml solution per mouse). Wet leaf extract was the most effective with 90.4% suppress...

Falciparum malaria is a protozoan disease caused by Plasmodium falciparum transmitted by the bite of infected Anopheles mosquitoes. This is a very common disorder in the tropics associated with myriad complications. We are presenting here acute pancreatitis as a sole presentation in a 35-yr old tribal man infected with falciparum malaria with high parasitemia. Acute pancreatitis is a well-known...

To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosomacruzi, correlating clinical signs with the parasitemia curve. We demonstrate that the acute phase of infection was marked by lethargy and loss of appetite. Si...

BACKGROUND The return of chloroquine-sensitive Plasmodium falciparum to the limited area of Blantyre, Malawi, has been well demonstrated in several studies. METHODS To characterize chloroquine susceptibility over a wide geographic area, infants and children aged 6-59 months were selected using 2-stage cluster sampling in 8 Malawian districts. Pyrosequencing of the pfcrt gene codon 76 region w...

Severe anemia is one of the major complications of malaria in Africa. We studied 2 populations, one in a village and the second in a periurban area in Mali, to understand the preventable factors in the disease. The 2 correlates of disease were parasitemia above 100 000 parasitized red blood cells per microliter (0.1 x 10(12)/L) and a low baseline hemoglobin level. All cases of moderate to sever...

Immunity to malaria is hard won, and yet it is imperfect. In areas of high malaria transmission, most symptomatic malaria and nearly all severe malaria and malaria deaths are in young children. This is the pattern in much of the malaria-endemic areas of West Africa, which bear the brunt of global malaria morbidity and mortality. Across the Sahel transmission of malaria is intense during the 3–4...

Recently Gordeuk et all have observed a drastic increase of the rate of parasite clearance in patients with asymptomatic Plasmodium falcipanun infection. They suggested that this may be partially caused by limitation of iron by chelation, although they argued that this may not be the only mechanism limiting growth of P falcipanun. Previous studies have shown elevated levels of neopterin in urin...

Falciparum malaria may be associated with significant morbidity and mortality. The degree of mortality and morbidity usually corresponds to the degree of parasitemia. Quinine and other antimalarial drugs are relatively slow acting and not always effective owing to the presence of drug resistance falciparum. Rapid reduction of the number of circulating parasites may be required. Exchange transfu...

A 58-year-old Japanese man with a high parasitemia of Plasmodium falciparum, returning from Uganda, was admitted to our hospital since his consciousness level rapidly deteriorated after the initial dose of mefloquine. Despite the parasitemia was cleared by quinine by day 7, the coma remained unchanged and diffuse leukoencephalopathy was detected on magnetic resonance image. Steroid pulse therap...