Children with Albright's hereditary osteodystrophy (AHO) suffering from spinal cord compression are rarely reported worldwide. The association of compressive myelopathy with AHO is not still well known. AHO is a rare heterogeneous group of inherited disorders and results from the GNAS mutation. AHO manifests in two different phenotypes, pseudohypoparathyroidism type Ia (PHP-Ia) and pseudopsedoh...

MRI of thoracic cord in tropical spastic paraparesis Tropical spastic paraparesis (TSP) is a disease occurring in Afro-Caribbeans following HTLV-1 retro-virus infection. There is some evidence that the geographical and ethnic distribution ofHTLV-1 illness is even wider' and HTLV-1 associated myelopathy (HAM) in Japan is probably the same disorder. Abnormalities are found on MRI of the brain in ...

Pseudotumor cerebri is a condition of increased intracranial pressure in the absence of clinical, laboratory or radiological pathology. Spinal intradural hematoma formation after lumboperitoneal shunt (LPS) implantation is very rare, but it can cause sudden and serious deterioration. In this report, we present a patient who developed an intradural hematoma following LPS operation. A 27-year-old...

Currently there is no secured ongoing funding in Australia for next generation sequencing (NGS) such as exome (ES) adult neurological disorders. Studies have focused on paediatric populations research or highly specialised settings, utilised standard NGS pipelines focusing only small insertions, deletions and single nucleotide variants, not explored impacts management detail.This prospective mu...

We report the cases of 5 adolescents with human T lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis, acquired in all but 1 case from the mother. The first symptom in all patients was difficulty in running, which was present for many years before the final diagnosis was made. Follow-up showed an indolent progression, regardless of treatment strategy.

Infection with human T cell leukaemia/lymphoma virus (HTLV) type I occurs mainly in Japan, central and west Africa, and the Caribbean basin. Infection confers a lifetime risk of 2-4% for adult T cell leukaemia or lymphoma and 0.2-5% for tropical spastic paraparesis. However, the incubation period for these conditions after naturally acquired infection may be several decades. The virus is transm...

INTRODUCTION The description of a neurological entity termed “Jamaican peripheral neuritis” by Strachan (1) in 1888 marked the beginning of more than a century of systematic clinical and scientific investigation into an endemic neurological syndrome that is now recognize as tropical spastic paraparesis. It required the work of Scott (2) in 1918 and finally Cruickshank (3) in 1956 to better clin...

A 41 year old man presented to the outpatient department with a three month history of difficulty in walking. He also had a history of positive sensory symptoms in the form of pins and needle sensation mostly below the waist. His symptoms had been progressive and there was no significant family history. He demonstrated a spastic gait and could only walk with assistance and support. DTR were hyp...

To cite: Valizadeh N, McCarthy P, Lynch JM. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013200679 DESCRIPTION A 66-year-old woman presented with a 9-month history of increasing difficulty in walking. Examination revealed asymmetric spastic paraparesis and a pyramidal pattern of weakness: Medical Research Council grade 4 on the left and 4+ on the right lower l...