Thyroid cancer is the most common malignancy in endocrine system, composed of four major types; papillary thyroid carcinoma, follicular thyroid carcinoma, anaplastic thyroid carcinoma, and medullary thyroid carcinoma. The incidence of thyroid cancer, especially differentiated thyroid cancer, is increasing in developed countries. Growing body of studies on molecular pathogenesis in thyroid cance...

A 61-year-old man, who was diagnosed with superior vena cava syndrome by papillary thyroid carcinoma, was referred to our hospital. A bulky thyroid tumor with tracheal invasion extended from the left neck to the right atrium without distant metastases. The risk of sudden death due to airway occlusion, tumor embolism or obstruction of the tricuspid valve led us to elect surgery. Extended resecti...

Differentiated thyroid cancer comprises papillary, mixed papillary-follicular and follicular adenocarcinomas. They are mostly hormone-sensitive and respond to thyroid-stimulating hormone (TSH) suppression. The standard treatment is total thyroidectomy, (131)I therapy and thyroid hormone suppression therapy. Adjuvant external radiotherapy is discussed controversially. Most authors recommend adju...

Disruption of Wnt signaling often happens in tumorigenesis, but whether Wnt signaling affects the early stages of thyroid tumor, such as papillary thyroid carcinoma, is still a question, especially in the papillary thyroid carcinoma without genomic RET/PTC mutation. In this study, we demonstrated the important function of Wnt signaling in papillary thyroid carcinoma K1 cells, which have no RET/...

Introduction Thyroid papillary carcinoma represents 75% of all thyroid cancer cases. It is more prevalent in the young and middle age group of patients. Distant metastases occur in 10% of cases. Metastases to lymph nodes can be the first sign of microcarcinoma. This is a case report where thrombophlebitis of popliteal vein and pulmonary embolic disease appeared to be the first manifestation of ...

Impact of nodal involvement in papillary thyroid cancer remains controversial. The incidence of nodal metastases is high and the presence of involved nodes has a negative impact on recurrence and possibly on survival as well, particularly in older patients. The risk of nodal disease increases with age, tumor size, and BRAF oncogene expression. Most thyroid surgeons sample the ipsilateral centra...

background and objective: thyroid cancer is the most frequent endocrine malignancy in the world and papillary carcinoma is the most frequent thyroid carcinoma. different markers used for determination of prognosis and vegfr is one of them. the aim of present study was to determine the expression of vascular endothelial growth factor receptor (vegfr) as a prognostic marker in papillary carcinoma...

Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer after papillary carcinoma. It usually grows slowly and is clinically indolent; but rarely, its aggressive forms with distant metastases can occur. We report here an uncommon case of bilateral orbital metastasis of FTC. A 70-year-old woman present...

we studied the clinical, radioisotopic, and pathologic characteristics and the incidence of cancer in clinically solitary cold nodules of the thyroid in an iodinedeficient area. the study included retrospective analysis of 765 patients who underwent thyroidectomy for a clinically single cold nodule in a ten-year period. we compared the pathological findings with clinical data. in pathological e...

Thyroid cancer is the most common of the endocrine malignancies and it represents <1% of all human tumors. The annual incidence of thyroid cancer varies considerably by geographic area, age and sex. A recent review reported an overall incidence of all types of thyroid cancer in the USA of 7.7 per 100 000 person-years, with rates of 11.3 per 100 000 woman-years and 4.1 per 100 000 man-years [1]....