INTRODUCTION Secondary pancreatic tumors are uncommon and account for 2-5% of pancreatic cancer. Tumors characterized most commonly with pancreatic involvement are lymphoma, renal cell and lung carcinomas. PRESENTATION OF CASE A 76-year-old female patient with obstructive jaundice as the primary symptom and inguinal lymphadenopathy is presented. Imaging revealed a bulky solitary solid pancrea...

BACKGROUND Little is known about the genetic and epigenetic changes that contribute to familial pancreatic cancers. The aim of this study was to compare the prevalence of common genetic and epigenetic alterations in sporadic and familial pancreatic ductal adenocarcinomas. METHODS DNA was isolated from the microdissected cancers of 39 patients with familial and 36 patients with sporadic pancre...

CONTEXT Pancreatic/para-pancreatic tuberculosis is an extremely rare clinical entity even in endemic regions. It can present as a cystic or solid pancreatic mass mimicking pancreatic malignancy. There are no specific imaging criteria and the clinical symptoms remain vague. Therefore, most cases are diagnosed after surgical exploration for presumed pancreatic neoplasia. CASE REPORT We report f...

CONTEXT Cytological assessment of pancreatic juice is commonly used to diagnose pancreatic ductal adenocarcinoma; however, the sensitivity of cytological assessment has been reported to be low. MicroRNAs are small RNAs regulating various cellular processes and have recently been identified as possible markers of malignant diseases including pancreatic ductal adenocarcinoma. OBJECTIVE The purp...

This study aimed to investigate the potency of silymarin (SMN) and melatonin (MEL) on restoring the pancreatic  cells in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were divided into five groups, including: control (C), untreated diabetic (D), SMN-treated diabetic (50 mg/kg, orally), MEL-treated diabetic (10 mg/kg, i.p.), and SMN plus MEL-treated diabetic rats. Diabetes was in...

This study aimed to investigate the potency of silymarin (SMN) and melatonin (MEL) on restoring the pancreatic  cells in streptozotocin (STZ)-induced diabetic rats. Male Wistar rats were divided into five groups, including: control (C), untreated diabetic (D), SMN-treated diabetic (50 mg/kg, orally), MEL-treated diabetic (10 mg/kg, i.p.), and SMN plus MEL-treated diabetic rats. Diabetes was in...

Genomic analyses aimed at the detection of high-level DNA amplifications were performed on 13 widely used pancreatic cancer cell lines and 6 pancreatic tumor specimens. For these analyses, array-based comparative genomic hybridization (Matrix-CGH) onto dedicated microarrays was used. In comparison with chromosomal CGH (eight amplifications), a >3-fold number of DNA amplifications was detected (...

BACKGROUNDS/AIMS With recent advances in pancreatic surgery, pancreaticoduodenectomy (PD) has become increasingly safe. However, pancreatic leakage is still one of the leading postoperative complications. An accurate prediction model for pancreatic leakage after PD can be helpful for pancreas surgeons. The aim of this study was to provide a new model that was simple and useful with high accurac...

Researchers have explored the feasibility of studying pancreatic juice movement to aid in pathological evaluations of pancreatico-biliary diseases. However, assessment of pancreatic juice movement is difficult. The early measurement approach of pancreatic juice movement was direct measurement of pancreatic juice involved insertion of a tube into the main pancreatic duct. However, since this met...

background resistance exercise is recommended as a useful therapeutic tool for the treatment of type 2 diabetes (t2d); however, the frequency of studies is inadequate to establish the precise mechanisms of any association between them. objectives in this study, we aimed to assess the effect of three months of resistance training on tcf7l2 expression in pancreatic tissues, serum insulin and gluc...