To determine the influence of the microenvironment on changes in gene expression, we did microarray analysis on three variant lines of a human pancreatic cancer (FG, L3.3, and L3.6pl) with different metastatic potentials. The variant lines were grown in tissue culture in the subcutis (ectopic) or pancreas (orthotopic) of nude mice. Compared with tissue culture, the number of genes of which the ...

The uptake of (75)Se Selenomethionine by the pancreas has been evaluated in 102 patients and compared with the secretin-pancreozymin test of pancreatic function. In groups of patients with chronic pancreatitis and cancer of the pancreas abnormal scans closely parallel the diminished exocrine secretion, especially bicarbonate output, following a submaximal dose of secretin. Thirty per cent of th...

The possible association between diabetes and cancer was first launched in 1932, when cancers in the intestine, uterus and pancreas were reported to occur more frequently among patients with diabetes [1]. However, it took some 70 years before the scientific community once more focused on this association. Several observational studies published over the last 10–15 years show unequivocally that ...

annular pancreas is a rare congenital condition of the pancreas where the pancreatic tissue either partially or completely covers the duodenum by forming a ring. endoscopic ultrasound is rarely considered as the first diagnosis tool for annular pancreas. we here present a 48 years old man who was primarily provisionally diagnosed with pancreatic mass and was planned for pancreatoduodenectomy. b...

Xanthogranulomatous pancreatitis (XGP) is a rare benign disease that may mimic or accompany other pancreatic diseases. Here we report a case of XGP initially suspected as malignant cystic neoplasm of the pancreas. A 64-year-old man had been incidentally found to have hypodense lesion at the body of pancreas during a lung cancer workup. All laboratory tests were within normal limits except that ...

A 64-year-old man was transferred to our division with a suspicion of gastric cancer. Computed tomography showed widespread irregular thickening of the stomach walls close to the liver and pancreas. Gastrointestinal fiberscopy showed a type 5 tumor in the upper to lower stomach, histologically diagnosed as tubular adenocarcinoma. Gastric cancer with hepatic and pancreatic invasion was diagnosed...

Automated pancreas segmentation in medical images is a prerequisite for many clinical applications, such as diabetes inspection, pancreatic cancer diagnosis, and surgical planing. In this paper, we formulate pancreas segmentation in magnetic resonance imaging (MRI) scans as a graph based decision fusion process combined with deep convolutional neural networks (CNN). Our approach conducts pancre...

Recent advances in human genomics and biotechnologies have profound impacts on medical research and clinical practice. Individual genomic information, including DNA sequences and gene expression profiles, can be used for prediction, prevention, diagnosis, and treatment for many complex diseases. Personalized medicine attempts to tailor medical care to individual patients by incorporating their ...

Maintaining the identity of acinar cells in the pancreas could help to prevent the development of pancreatic cancer.

Squamous cell carcinoma (SCC) of pancreas is a rare histotype of pancreatic ductal carcinoma which is distinct from pancreatic adenocarcinoma (AC). Although there are standard treatments for pancreatic AC, no precise therapies exist for pancreatic SCC. Here, we screened 1033 cases of pancreatic cancer and identified 2 cases of pure SCC, which were pathologically diagnosed on the basis of findin...