Proper patterning and growth of oral structures including teeth, tongue, and palate rely on epithelial-mesenchymal interactions involving coordinated regulation of signal transduction. Understanding molecular mechanisms underpinning oral-facial development will provide novel insights into the etiology of common congenital defects such as cleft palate. In this study, we report that ablating Wnt ...

Development of the mammalian secondary palate involves multiple steps of highly regulated morphogenetic processes that are frequently disturbed during human development, resulting in the common birth defect of cleft palate. Neither the molecular processes governing normal palatogenesis nor the causes of cleft palate is well understood. In an expression screen to identify new transcription facto...

Background: Cleft lip and/or palate are the most common orofacial malformations. Many studies, especially in developed countries have been conducted on this malformation, but in Burkina Faso, data are scarce and they are not specific to children. The aim of this study was to report the epidemiological, clinical and therapeutic aspects of cleft lip and/or palate in children in a low-income count...

Nonsyndromic cleft lip & palate is a congenital deformity of multifactorial origin. Various etiologic candidate genes have been reported with conflicting results, according to the race and population studied. Numerous efforts made understand etiology cleft/palate so as predict its occurrence thus enable prevention. The FGF regulation pathway also plays major role in craniofacial development. FG...

Introduction: Cleft lip and palate, the most common developmental deformity, is seen worldwide and the etiology involves a combination of genetic and environmental factors. The purpose of this study was to determine the maternal risk factors associated with the development of cleft lip and cleft palate. Materials and Methods: We conducted a case control study at the Women’s Hospital in Culiacan...

Speakers make effective adaptation to unfavourable articulatory conditions and they successfully compensate for the perturbation. The influence of artificial palate (6mm thick in the region of the alveolar ridge) on the reorganization of articulatory movements when speakers practise pronunciation with the artificial palate is investigated. Five female students of normal articulatory and hearing...

The facial processes involved in primary palate formation undergo epithelial fusion in a manner morphologically analogous to that observed during secondary palate formation. We have used whole embryo culture to analyze the synthesis of macromolecules (DNA, protein glycoprotein) in the primary palate, based on the incorporation of various labeled precursors. The results of this study demonstrate...

Cleft lip and palate are among the most common craniofacial anomalies of the human species causing considerable morbidity to affected individuals. The etiology of isolated or non-syndromic cleft lip and palate is complex and heterogeneous, and its occurrence is associated with the interaction of different genetic and environmental factors. To explore the genetic and environmental factors involv...

We report the case of a 16-year-old female patient with taste impairment of the soft palate. After receiving a skull fracture due to a traffic accident, she experienced the taste of bitter chocolate. CT showed the fracture around the right temporal bone. Electrogustometry showed that the decreased sensation of taste was restricted to the right soft palate. Shirmer test showed that lacrimal secr...

OBJECTIVE To assess dental age in children with a complete unilateral cleft lip and palate and to compare this with a noncleft control group. DESIGN Two-group, mixed-longitudinal cohort study. SETTING Cleft group from an academic center for cleft lip and palate treatment. Noncleft control group from the same population. PATIENTS Participants included 70 Caucasian children with a full comp...