The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp...

A new indolinepeptide (3) was isolated, together with two known compounds, a cerebroside (1) and an alloxazine (2), from silkworm larvae infected with Paecilomyces sp. J300. On the basis of spectroscopic data, their structures were elucidated as (4E, 8E, 2S, 2'R, 3R)-N-2'-hydroxyhexadecanoyl-1-O-beta-D-glucopyranosyl-9-methyl-4, 8-sphingadienine (1), 7,8-dimethylalloxazine (2) and 3beta,5-dihyd...

A filamentous fungus that caused a fatal systemic infection in a dog has been identified as the new species Sagenomella chlamydospora. When the case was initially reported, the fungus was identified as Paecilomyces sp. This study emphasizes how difficult can be the identification of the causative agent of an infection when an uncommon microorganism is involved. This is the first time that this ...

Pulp and paper mill effluent is posing a serious threat to the water and soil components of the environment due to its brown colour and high level of toxicity. Fungal treatment is one of the efficient methods for treating pulp and paper mill effluent. In the present study, for the treatment of from pulp and paper industry, nine efficient fungal strains including Phanerochaete chrysosporium, ded...

Three fungal strains were found to be capable of bioleaching rare earth elements from monazite, a rare earth phosphate mineral, utilizing the monazite as a phosphate source and releasing rare earth cations into solution. These organisms include one known phosphate solubilizing fungus, Aspergillus niger ATCC 1015, as well as two newly isolated fungi: an Aspergillus terreus strain ML3-1 and a Pae...

A resistant and capable fungal strain in removing hexavalent chromium was isolated from an environment near of Chemical Science Faculty, located in the city of San Luis Potosí, Mexico. The strain was identified as Paecilomyces sp., by macro- and microscopic characteristics. Strain resistance of the strain to high Cr (VI) concentrations and its ability to reduce chromium were studied. When it wa...

die-back disease caused by paecilomyces variotti is one of the most destructive diseases of pistachio in iran. in this study, genetic diversity of paecilomyces variotti isolates was investigated with ssr marker, using six primers pairs. sampling was done from pistachio gardens in different geographical zones of kerman province during summer 2013. various fungal isolates were isolated from infec...

Sorghum (Sorghum bicolor Moench) is the fifth most produced cereal worldwide. However, some varieties of this cereal contain antinutritional factors, such as tannins and phytate that may form stable complexes with proteins and minerals which decreases digestibility and nutritional value. The present study sought to diminish antinutritional tannins and phytate present in sorghum grains. Three di...

DNAtopoisomerases I and II are enzymes that alter DNA conformation through a concerted breaking and rejoining of DNAstrands1*. Recently topoisomerase II has been identified as the primary cellular target for a number of clinically important antitumor agents with diverse and unrelated chemical structures2'3*. These antitumor drugs, termed "topoisomerase II poisons" have the commonproperty of sta...