Terbutaline is known to be an effective drug in the treatment of asthma which acts by P32 receptor stimulation in the lung.' If given in large doses this agent may produce side effects-such as tremor, headache, and tachycardia. Children seem to be fairly tolerant of such side effects and therefore may continue to obtain benefit at doses higher than currently recommended. The present study was u...

In common with other positive-strand RNA viruses, replication of feline calicivirus (FCV) results in rearrangement of intracellular membranes and production of numerous membrane-bound vesicular structures on which viral genome replication is thought to occur. In this study, bioinformatics approaches have identified three of the FCV non-structural proteins, namely p32, p39 and p30, as potential ...

The in vivo fate of nanomaterials strongly determines their biomedical efficacy. Accordingly, much effort has been invested into the development of library screening methods to select targeting ligands for a diversity of sites in vivo. Still, broad application of chemical and biological screens to the in vivo targeting of nanomaterials requires ligand attachment chemistries that are generalizab...

PROCEDURE AND RESULTS Neoplasms were observed in two experimental groups of rats, i.e., (a) animals surviving a single Luso dose of P32 (4.5 /tc. per gram of body weight), and (b) those surviving repeated injections of P32 (1.5 /uà ̈. per gram of body weight every 3 weeks) for a total dose of 9 or 12 ¡ic. per gram. Adult white male rats of the C. F. Wistar strain, which weighed about 150 gin. e...

Human milk compared with infant formulas contains considerably more sialic acid (SA) and cholesterol. Because both compounds accumulate rapidly in the frontal cortex in infancy, it has been suggested these compounds may be conditionally essential nutrients for brain development. A limited number of animal studies demonstrate that dietary cholesterol and SA increase cortical cholesterol and SA c...

| Lumpy skin disease (LSD) is an infectious viral disease of cattle that results in serious economic and international trade consequences. Recently, hard ticks have been incriminated in lumpy skin disease virus (LSDV) transmission. The present study attempted to investigate the role of Rhipicephalus annulatus ticks, collected from naturally infected animals, in the transmission of LSDV. A total...

Reports implicating microglia-derived nerve growth factor (NGF) during programmed cell death in the developing chick retina led us to investigate its possible role in degenerative retinal disease. Freshly isolated activated retinal microglia expressed high molecular weight forms of neurotrophins including that of nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3, and ...

The kinetics of reduction and oxidation of soluble chromium in various soils (peat, clay, sand, and luvi-chromic cambisols) were studied at constant soil moisture and constant temperature. A total of 1500 g of each soil was incubated with different concentrations of aqueous solutions of K2Cr2O7 or CrCl3 [1-1000 μg (g of dry soil)-1]. The total exchangeable chromium and Cr(VI) were analyzed in s...