The objective of this prespecified TRINITY study subgroup analysis was to assess the efficacy and safety of triple-combination treatment with olmesartan medoxomil (OM) 40 mg, amlodipine besylate (AML) 10 mg, and hydrochlorothiazide (HCTZ) 25 mg vs the component dual-combination treatments in obese (body mass index [BMI] ≥30 kg/m(2) ) and nonobese (BMI <30 kg/m(2) ) hypertensive participants. Th...

To determine the effect of gender on outcome, the male hazard ratio for progression-free survival (HRPFS-male) was determined in patients with diffuse large B-cell lymphoma (DLBCL). In young patients (MapThera International Trial study), HRPFS-male was 1.3 (P = .092) without and 1.1 (P = .660) with rituximab. In elderly patients (RICOVER-60 study), HRPFS-male was 1.1 (P = .348) with CHOP but in...

Background Platelet-rich plasma (PRP) has shown to be a general stimulation for repair. Purpose To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis. Study Design Randomized controlled trial; Level of evidence, 1. Patients The trial was conducted in 2 teaching hospitals in the Netherlands. One hundred patients with chronic ...

BACKGROUND Platelet-rich plasma (PRP) has shown to be a general stimulation for repair. Purpose To determine the effectiveness of PRP compared with corticosteroid injections in patients with chronic lateral epicondylitis. STUDY DESIGN Randomized controlled trial; Level of evidence, 1. PATIENTS The trial was conducted in 2 teaching hospitals in the Netherlands. One hundred patients with chro...

OBJECTIVE To study whether prednisolone reduces sequelae in Bell's palsy. DESIGN Prospective, randomized, double-blind, placebo-controlled, multicenter trial with 12 months of follow-up. SETTING Seventeen referral centers. PATIENTS In all, 829 patients aged 18 to 75 years. INTERVENTIONS Randomization within 72 hours in a factorial fashion to placebo plus placebo (n = 206); prednisolone,...

BACKGROUND High-dose aspirin (≥500 mg daily) reduces long-term incidence of colorectal cancer, but adverse effects might limit its potential for long-term prevention. The long-term effectiveness of lower doses (75-300 mg daily) is unknown. We assessed the effects of aspirin on incidence and mortality due to colorectal cancer in relation to dose, duration of treatment, and site of tumour. METH...

A 5 X 5 Latin square design was used to study the effects on nitrogen balance, wool growth and plasma amino acids of infusing methionine and (or) glucose into the abomasum of growing wethers fed formaldehyde-treated Coastal bermudagrass (F-CBG) or untreated Coastal bermudagrass hay. Daily treatments were: (1) CBG; (2) F-CBG + 3 g methionine (met); (4) F-CBG + 96 g glucose and (5) F-CBG + 3 met ...

OBJECTIVES To investigate whether it is possible to determine signs of imminent dying and change in pain and symptom intensity during pharmacological treatment in nursing home patients, from day perceived as dying and to day of death. DESIGN Prospective, longitudinal trajectory trial. SETTING Forty-seven nursing homes within 35 municipalities of Norway. PARTICIPANTS A total of 691 nursing...