Abstract. Organic aerosols are key components of the Earth's atmospheric system. The phase state organic is known to be a significant factor in determining aerosol reactivity, water uptake and lifetime – with wide implications for cloud formation, climate, air quality human health. Unsaturated fatty acids contribute urban cooking emissions sea spray aerosols. These compounds, exemplified by ole...

A series of 2',3'-dideoxy-3'-fluoro-D-apiosyl nucleosides 15, 16, 17 and 18 were synthesized enantiomerically with L-Gulonic-γ-lactone as the starting material. The reduction of butenolide 1 with DIBAL-H followed by the Luche procedure afforded the allylic alcohol 2. Ozonolysis and the reduction of compound 4 induced the cyclized lactol, which was acetylated to give the acetate 7. Condensation ...

A concise enantioselective synthesis of malyngamide W (1) and its 2'-epimer was described. The strategy was based on three key steps: (1) ozonolysis of compound 11 which was derived from (R)-(-)-carvone 8, followed by copper-iron-catalyzed rearrangement to give the key cyclohex-2-enone intermediate 5, (2) Nozaki-Hiyama-Kishi coupling reaction between aldehyde 4 and iodide 14 to afford alcohol 3...

Stereoselective synthesis of variably protected α- and β-l-Ara4N glycosyl H-phosphonates as key intermediates in the syntheses of β-l-Ara4N-modified LPS structures and α-l-Ara4N-containing biosynthetic precursors is reported. A facile one-pot approach toward β-l-Ara4N glycosyl H-phosphonates includes anomeric deallylation of protected 4-azido β-l-Ara4N via terminal olefin isomerization followed...

A high-resolution GC/MS method using the Agilent 7890 GC and the Agilent 5975C Series GC/MSD has been developed and validated for the analysis of potentially harmful ginkgolic acid (GA) species that is superior to current HPLC methods. Ozonolysis was used to identify the position of double bonds in four different unsaturated GA isomers. The 15:1 isomer was dominant in all the plant samples, and...