BACKGROUND & AIMS Branched-chain amino acids (BCAA) reduce the incidence of hepatocellular carcinoma (HCC) in patients with cirrhosis. However, the mechanisms that underlie these effects remain unknown. Previously, we reported that oxidative stress in male transgenic mice that expressed hepatitis C virus polyprotein (HCVTgM) caused hepatic iron accumulation by reducing hepcidin transcription, t...

Multiple myeloma is a malignant still incurable plasma cell disorder. Pharmacological treatment based on proteasome inhibition has improved patient outcome; however, bortezomib-resistance remains a major clinical problem. Inhibition of proteasome functionality affects cellular iron homeostasis and iron is a potent inducer of reactive oxygen species and cell death, unless safely stored in ferrit...

In healthy humans, cerebral oxygen desaturation during exercise affects motor unit recruitment, while oxygen supplementation enhances cerebral oxygenation and work capacity. It remains unknown whether in patients with chronic obstructive pulmonary disease (COPD), the well-documented improvement in exercise tolerance with oxygen supplementation may also be partly due to the increase in cerebral ...

ObjectiveTo assess the success rate, procedure time, and adverse events of intrathecal administration nusinersen via paramedian approach in adolescents adults with spinal muscular atrophy (SMA) associated scoliosis.MethodsSeven patients genetically confirmed SMA (age, 12–40 years) were included. Intrathecal was performed using fluoroscopy after determination largest interlaminal foramen among L...

Objective. This paper aims to determine the respiratory manifestations, radiologic findings, and management of coronavirus-19 (COVID-19) among hospitalized children different age groups based on a systematic review literature. Methodology. We searched MEDLINE, Google Scholar, Cochrane, MedRvrix databases for relevant studies pediatric COVID-19 done between January 1 May 25, 2020. Data demograph...

BACKGROUND Autophagy has been reported to be essential for pre-implantation development and embryo survival. However, its role in placental development and regulation of autophagy during pregnancy remain unclear. The aims of this study were to (1) study autophagy by characterizing changes in levels of beclin-1, DRAM, and LC3B in human placenta throughout gestation; (2) determine whether autopha...

Introduction: The aim of this study was to investigate the structural changes of cardiac tissue in response to L-carnitine supplementation and endurance training in Wistar male rats toxicated by steroid anabolic hormone. Methods: 36 male Wistar rats aged 8-12 weeks (weight 195±7.94g) were randomly divided into six groups: Control, Non-treated, Boldenone (5 mg/kg), L-carnitine (100 mg pe...

Background and objectives: Sedentary life style and high-fat diet are one of the key causes of coronary artery disease. The aim of this study was to evaluate effects of periodic exercise and consumption of fenugreek seed extract on the expression of oxidized low-density lipoprotein (oxLDL) and reactive oxygen species (ROS) genes in patients with coronary artery occlusion. Methods: The present ...

of supportive care and emergency medicine is necessary for the successful medical management of avian patients. The basic concepts of emergency and supportive care of small animal medicine apply to birds, but modifications must be made to compensate for their unique anatomy and physiology. Supportive care including fluid therapy, nutritional support, and heat and oxygen supplementation is criti...

OBJECTIVE To determine whether regulating vitamin C (ascorbic acid: AA) intake to achieve higher or lower plasma concentrations was associated with improved clinical outcome. DESIGN A double blind, randomised controlled trial. SETTING Neonatal intensive care unit at Christchurch Women's Hospital. PATIENTS Infants with birth weight <1500 g or gestation <32 weeks, admitted to the unit withi...