The biomolecule chelidonic acid (H2chel, 4-oxo-4H-pyran-2,6-dicarboxylic acid) has been used to build new coordination polymers with the bridging N,N?-ligands 4,4?-bipyridine (4,4-bipy) and 1,2-bis(4-pyridyl)ethane (bpe). Four compounds have obtained as single crystals: 1D cationic [M(4,4-bipy)(OH2)4]2+ chelidonate anions water molecules in second sphere 1?[Zn(4,4-bipy)(H2O)4]chel·3H2O (2) two ...

THE TITLE COMPOUND (SYSTEMATIC NAME 9a-hydr-oxy-3,4a,5-trimethyl-4a,6,7,8a,9,9a-hexa-hydro-4H,5H-naphtho[2,3-b]furan-2,8-dione), C(15)H(20)O(4), is a sesquiterpene lactone showing the typical eremophilanolide skeleton, which has been isolated from the plant Senecio candidans collected in the Chilean Magallanes region. The present study confirms the atomic connectivity assigned on the basis of (...

Crystallizing the cobalt(II) salt of the azo dye Orange G from water was found to give the solvent-separated ion-pair species hexa-aqua-cobalt(II) 7-oxo-8-(2-phenyl-hydrazin-1-ylidene)-7,8-dihydro-naphthalene-1,3-disulfonate tetra-hydrate, [Co(H(2)O)(6)](C(16)H(10)N(2)O(7)S(2))·4H(2)O. The asymmetric unit of the cobalt(II) salt contains three independent octa-hedral [Co(OH(2))(6)](2+) cations, ...

In this study, 4',7-diacetoxyapigenin [4-(7-acetoxy-5-hydroxy-4-oxo-4H-chromen-2-yl) phenyl acetate] was synthesized for the first time. Its chemical structure was identified by UV, ESI-MS, (1)H and (13)C-NMR. It could inhibit the proliferation of Hep G2 cells in a dose-dependent manner and induce the significant increase of the G0/G1 cell population. After treatment by 4',7-diacetoxyapigenin, ...

Inappropriate thrombus formation within blood vessels is the leading cause of mortality in the industrialized world. Factor Xa (FXa) is a trypsin-like serine protease that plays a key role in the blood coagulation cascade and represents an attractive target for anticoagulant drug development. From a high-throughput in vitro mass screen of our chemical library, we identified 4-[5-[(2R,6S)-2, 6-d...

Isothiazolopyridines, pyridothiazines and pyridothiazepines are important compounds that possess valuable biological activities. This paper reports on the synthesis of these compounds using both conventional chemical methods and modern microwave techniques. 3-Bromo-6-hydroxy-4-methyl-2-thioxo-2,3-dihydropyridine-3-carboxamide, 5-arylazo-6-hydroxy-4-methyl-2-thioxo-1,2-dihydropyridine-3-carboxam...

In the title compound, [Cu(C(10)H(8)N(3)O(2))(2)]·4H(2)O, the Cu(II) ion has a distorted octa-hedral coordination formed by four O [Cu-O = 2.051 (3)-2.083 (4) Å] and two N [Cu-N = 1.985 (4) and 1.996 (4) Å] atoms from two tridentate bis-(1-oxo-2-pyrid-yl)aminate ligands. In the two ligands, the pyridyl rings form dihedral angles of 21.0 (1) and 15.5 (1)°. The crystal packing exhibits an extensi...

250 words Introduction: 315 words Discussion: 950 words Abbreviations: HPLC, high performance liquid chromatography; LC-MS/MS, liquid chromatography/tandem mass spectrometry; RKIP, Raf1-kinase inhibitor protein; HEPES, 2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic acid; DMSO, dimethylsulfoxide ; Tris, tris(hydroxymethyl)aminomethane, SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel elec...

3-Hydroxy-2-(4’-methoxyphenyl)-4-oxo-4H-l-benzopyran (HMPB) forms a yellow colored (1:3) complex with niobium (V), which is extracted into dichloromethane from 1.04–4.40 molL -1 HClO4 solution showing an absorption maximum at 398 – 412 nm (figure curve A: 1.0 μg Nb ml -1 versus blank; curve B: blank versus DCM) with Beer's law range of 0–1.3 μg Nb ml -1 , molar absorptivity of 3.764 10 4 L mol ...

A group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a COX-2 SO2Me pharmacophore at the para position of the C-2 or C-4 phenyl ring, in conjunction with a C-4 or C-2 phenyl (4-H) or substituted-phenyl ring (4-F,4-Cl,4-Br,4-OMe,4-Me, 4-NO2), were designed for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors. These target 5-oxo-1,4,5,6,7,8 hexahydroquino...