background: there is much evidence indicating that natural substances from edible and medicinal plants possess powerful antioxidant and hepatoprotective activities. the objective of the present study was to investigate the potential hepatoprotective effect of silymarin in fish exposed to malathion. methods: zebra cichlid fish were allocated into five groups of which one group received normal fe...

enhancement of antioxidant capacity of plants by natural antioxidants obtained from medicinal plants can be a simple way to produce stress tolerant plants. zataria multiflora essential oil (zo) is one of the useful antioxidants with potent antioxidant activity. zo is insoluble in water and can be degraded by light, oxygen, and high temperature. incorporation of zo into poly vinyl alcohol (pva) ...

oxidative stress and mitochondrial dysfunction are the main suggested mechanisms for neurodegenerative diseases. in this study, we have evaluated the effects of epicatechin (ec) on mitochondrial damage induced by homocycteine (hcy) using isolated rat hippocampus mitochondria in vivo . ec (50 mg/kg) was gavaged daily for a period of 10 days, starting 5 days prior to hcy (0.5 μmol/μl) intra hippo...

infertility is one of the most stressful conditions amongst married couples. male factor infertility is implicated in almost half of these cases. recent advances in the field of reproductive medicine have focused the attention of many researchers to consider reactive oxygen species (ros) as one of the mediators of infertility causing sperm dysfunction. although, ros is involved in many physiolo...

cyfluthrinm[cyano[4-fluoro-3-phenoxyphenyl]-methyl-3-[2,2-dichloroethenyl]-2,2-dimethyl-cyclo propane carboxylate] is a synthetic pyrethroid insecticide, that has both contact and stomach poison action. the present study evaluated the long-term toxic effects of cyfluthrin on antioxidant status in buffalo calves. oral administration of cyfluthrin at a dose rate of 10 and 20 mg/kg/d for 11 consec...

considering the high prevalence of osteoarthritis (oa) and since until now there has not been any human studies to evaluate the effect of sesame in oa patients, this study was designed to assess the effect of administration of sesame on inflammation and oxidative stress in patients with knee oa. fifty patients with knee oa were allocated into two groups namely control and sesame group. 25 patie...

helicobacter pylori infection is a common gastrointestinal infection that can cause pathological effects, increase oxidative stress and induce an inflammatory response in gastric mucosa. inflammatory aspects may prompt the production of radical oxygen substance (ros) which may damage cells and release 8-hydroxydyoxyguanosine (8-ohdg) to serum. in this study, we evaluate the prevalence of h. pyl...

the present study was aimed to evaluate the therapeutic potential of pimpinella tirupatiensis (pt) by assaying the activities of selective mitochondrial enzymes in streptozotocin induced diabetic rats. diabetic rats showed a significant (p < 0.01) reduction in the activities of oxidative enzymes succinate dehydrogenase (sdh), malate dehydrogenase (mdh), glutamate dehydrogenase (gdh) and isocitr...

anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet ccl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). group i (control), while group ii was given ccl4 (3 ml /kg/day, ip). animals of groups iii received only propofol (10 mg/kg/day, ip). group iv was given propofol+ ccl4. group v was admin...

metals can cause oxidative stress by increasing the formation of reactive oxygen species (ros), which make antioxidants incapable of defiance against growing amounts of free radicals. metal toxicity is related to their oxidative state and reactivity with other compounds. however, several reports about metals have been published in the recent years. mitochondria, as a site of cellular oxygen con...