Klotho is an aging-suppressor gene. The purpose of this study is to investigate the binding sites (receptors) and function of short-form Klotho (Skl). We showed that Skl physically bound to multiple proteins. We found physical and functional interactions between Skl and S-formylglutathione hydrolase (FGH), a key enzyme in the generation of the major cellular anti-oxidant GSH, using co-immunopre...

Ceruloplasmin is a plasma protein that carries most of the copper found in the blood. Although its elevation after inflammation and trauma has led to its classification as an acute phase protein, its physiological role is uncertain. A frequently reported activity of ceruloplasmin is its ability to suppress oxidation of lipids. In light of the intense recent interest in the oxidation of plasma L...

Despite the growing evidence that plasma homocysteine is a cardiovascular risk factor, the mechanism behind the vascular injuries is still unknown. Studies are difficult as a result of the fact that little is known about the formation of different homocysteine species in vivo. Since extracellular glutathione and cysteine may influence the formation of different homocysteine species, we have in ...

Platinum complexes are the most widely used anticancer drugs; however, new generations of agents are needed. The organoiridium(III) complex [(η(5) -Cp(xbiph) )Ir(phpy)(Cl)] (1-Cl), which contains π-bonded biphenyltetramethylcyclopentadienyl (Cp(xbiph) ) and C^N-chelated phenylpyridine (phpy) ligands, undergoes rapid hydrolysis of the chlorido ligand. In contrast, the pyridine complex [(η(5) -Cp...

The selective oxidation of alcohols to aldehydes has attracted a lot attention because its potential use in agrochemicals, fragrances, and fine chemicals. However, due homogenous catalysis, low yield, selectivity, hazardous oxidants, traditional approaches have lost their efficiency. co-precipitation method was used synthesize the silver-cobalt bimetallic catalyst supported on functionalized mu...

oxidation reaction of indole to isatin was performed in the presence of fe3o4 nanoparticles (as catalyst) and commercial grade perhydrol (as oxidant). magnetite nanoparticles were synthesized via chemical precipitation method and characterized by xrd and tem techniques. the efficiency of reaction was obtained from gc analysis of the mixture. the catalyst was easily separated from the reaction m...

Oral treatment with 50 mg Kg(-1) day(-1) of crude methanol extract of Morinda citrifolia leaves for 14 days significantly increased the anti-oxidant enzymes, like catalase, glutathione peroxidase (GSHPx) and superoxide dismutase (SOD), and anti-oxidants like glutathione (GSH) and ascorbic acid decreased in lymphoma-bearing mice.

Studies on natural compounds are of interest in now a day, due to their satisfactory health benefits with low toxicity. Herbs and spices have been added to different types of food to impart flavour as well as to improve storage stability due to their anti-oxidant effects. Anti-oxidants play a major role in curing degenerative diseases. In current scenario many synthetic antioxidants are commonl...

Buckwheat sprouts contain various bioactive compounds including rutin which have a number of biological activities. We have previously shown that buckwheat sprouts (TBWE) treated with methyl jasmonate (MeJA) significantly increased the amount of phenolics and the antioxidant activity. The aim of this study was to demonstrate the effect of TBWE on anti-adipogenesis and pro-oxidant enzyme in 3T3-...