Hyperoxaluria can lead to multiple pathologic conditions such as recurrent urolithiasis, oxalosis, nephrocalcinosis and even renal failure, but there is no known oxalate-degrading pathway in the human body, and current therapeutic options for patients with hyperoxaluria are limited. Oxalyl-CoA decarboxylase and formyl-CoA transferase are the key enzymes in the oxalate catabolism of Oxalobacter ...

The presence of calcium oxalate crysta.ls in the human kidney ,vas reported 111 1959 ( 15) . This was later follo'Ned by many studies in which the same kind ?f crystals were found in the human thYl:Old (17), retina oculi (5, 18), and myocardIUm ( 2). These ealciu m oxal ate crystals ha ~e been thought to have a different pathologIC meaning from crystal formation in primary oxalosis. There have ...

Oxalic acid is an end product of human metabolism and does not appear to be needed for any process in the body. Under normal conditions the daily load of oxalate deriving from endogenous production and intestinal absorption is fully excreted by the kidneys. Up to a certain extent renal oxalate excretion may even keep pace with an elevated oxalate load, yet at the expense of hyperoxaluria, a maj...

Sodium glucose transporter (SGLT)-2 inhibition has renoprotective effects in diabetic kidney disease. Whether similar effects can be achieved also in non-diabetic kidney disease is speculative. Chronic kidney disease was induced in C57BL/6N mice by feeding an oxalate-rich diet for 14 days, known to induce nephrocalcinosis-related tubular atrophy and interstitial fibrosis without directly affect...

Oxalate is a normal constituent of human urine. Since oxalate is found in many foods it has frequently been assumed that urinary oxalate is largely, if not entirely, of dietary origin. However, animal studies have shown that oxalate may arise endogenously, and glycine, glyoxylic acid, glycolic acid (3-5) and ascorbic acid (6, 7) have been shown to be precursors of urinary or tissue oxalate unde...

Objective The purpose of this study was to find out the aetiology of end-stage renal failure (ESRF) in children in Jordan. Subjects and Methods This was a multicentre retrospective study at five participating hospitals. Data collection included medical record review for age, gender, aetiology of ESRF, modality of renal replacement therapy (RRT) and outcome. End-stage renal failure was defined...

INTRODUCTION Influenza A (H1N1) virus was first reported on April 2009 and, since then, several studies have reported the characteristics concerning the clinical presentation and pulmonary involvement. However, accurate information about the acute kidney injury (AKI) and kidney histopathological findings in these patients remain scarce. OBJECTIVE To describe the kidney histopathological findi...

BACKGROUND Urinary macromolecules contribute to promoting or inhibiting crystal retention in renal tissue and stone formation. Osteopontin (OPN) and Tamm-Horsfall protein (THP) are the most important proteins involved in this process. Although these two proteins were discovered a long time ago, their role in setting kidney stone formation has not yet been fully investigated. We conducted a stud...