نتایج جستجو برای: oxa 2

تعداد نتایج: 2527005  

Journal: :The Journal of antimicrobial chemotherapy 2009
Po-Liang Lu Michel Doumith David M Livermore Tyen-Po Chen Neil Woodford

OBJECTIVES We investigated the molecular epidemiology of carbapenem-resistant Acinetobacter baumannii from a Taiwanese hospital and determined the mechanisms responsible for resistance. METHODS Ninety-two consecutive meropenem-resistant A. baumannii isolates collected between January 2005 and June 2007 were screened for genes encoding OXA carbapenemases, metallo-beta-lactamases and for the ca...

Journal: :Journal of clinical microbiology 2015
Gina K Thomson Sameh AbdelGhani James W Snyder Kenneth S Thomson

Enterobacteriaceae producing class D OXA-48 and OXA-48-like carbapenemases are an increasing concern. Detection is a diagnostic challenge because (i) some isolates are carbapenem susceptible and may go unrecognized, (ii) tests that detect carbapenem hydrolysis may be insensitive due to the relatively weak hydrolytic activity of these enzymes, (iii) the enzymes are not significantly inhibited by...

2014
Alexsandro F. dos Santos Rodrigo Cristiano Petrônio F. Athayde-Filho Adailton J. Bortoluzzi

In the title compound, C11H10N2O3, which is a potential bioactive compound, the benzene and oxa-diazole rings are approximately coplanar, with an inter-ring dihedral angle of 4.14 (2)°, while the ester plane is rotated out of the benzene plane [dihedral angle = 82.69 (9)°]. In the crystal, the mol-ecules form layers down the a axis with weak π-π inter-actions between the oxa-diazole and benzene...

2015
Roberto Romeo Caterina Carnovale Salvatore V Giofrè Maria A Chiacchio Adriana Garozzo Emanuele Amata Giovanni Romeo Ugo Chiacchio

A novel series of 2'-oxa-3'-aza-4'a-carbanucleosides, featured with a triazole linker at the 5'-position, has been developed by exploiting a click chemistry reaction of 5'-azido-2'-oxa-3'-aza-4'a-carbanucleosides with substituted alkynes. Biological tests indicate an antitumor activity for the synthesized compounds: most of them inhibit cell proliferation of Vero, BS-C-1, HEp-2, MDCK, and HFF c...

Journal: :The journal of physical chemistry. A 2011
Takatoshi Ichino Stephanie M Villano Adam J Gianola Daniel J Goebbert Luis Velarde Andrei Sanov Stephen J Blanksby Xin Zhou David A Hrovat Weston Thatcher Borden W Carl Lineberger

The photoelectron spectrum of the oxyallyl (OXA) radical anion has been measured. The radical anion has been generated in the reaction of the atomic oxygen radical anion (O(•-)) with acetone. Three low-lying electronic states of OXA have been observed in the spectrum. Electronic structure calculations have been performed for the triplet states ((3)B(2) and (3)B(1)) of OXA and the ground doublet...

Journal: :Journal of clinical microbiology 2012
Mohammed O Abdelaziz Celestino Bonura Aurora Aleo Ramadan A El-Domany Teresa Fasciana Caterina Mammina

Two genetically unrelated OXA-163-carrying Klebsiella pneumoniae strains were identified from two infection cases in June 2009 and May 2010 in Cairo, Egypt. OXA-163-producing Enterobacteriaceae had been previously reported in Argentina only. Both patients had no history of travel abroad. The emergence of this newly recognized OXA-48-related β-lactamase able to hydrolyze cephalosporins and carba...

Journal: :The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2013
Andreza F Martins Aline Borges Mariana Pagano Libera Maria Dalla-Costa Afonso L Barth

Carbapenemases production, either metallo-lactamases (MBLs), KPC or oxacillinases (OXA), is the main resistance mechanism responsible for resistance phenotype to carbapenems in Acinetobacter.1 While for MBLs and KPCs there are some screening tests for their detection,2,3 the same is not true for oxacillinases. During the investigation of a large outbreak, we analyzed 584 carbapenem-resistant Ac...

Journal: :The Journal of antimicrobial chemotherapy 2014
Witchuda Kamolvit Paul G Higgins David L Paterson Harald Seifert

OBJECTIVES Bacteria of the genus Acinetobacter are increasingly being isolated in hospitals and are recognized as emerging nosocomial pathogens. Species identification is difficult and there is a need for simple molecular methods to differentiate between the species. Naturally occurring oxacillinase genes (blaOXA) have been identified in several Acinetobacter species and their detection by PCR ...

2015
Sara Kooti Mohammad Motamedifar Jamal Sarvari

BACKGROUND The emergence of multidrug-resistant Acinetobacter baumannii complicates the therapy of the related infections. Hospital isolates of A. baumannii are usually multidrug-resistant. The problem is compounded by increasing resistance to broad-spectrum antibiotics including carbapenems. OBJECTIVES The aim of this study was to determine antimicrobial susceptibility patterns and distribut...

Journal: :European Journal of Medicinal Chemistry 2021

The occurrence of resistances in Gram negative bacteria is steadily increasing to reach extremely worrying levels and one the main causes resistance massive spread very efficient ?-lactamases which render most ?-lactam antibiotics useless. Herein, we report development a series imino-analogues ?-lactams (namely azetidinimines) as non-covalent inhibitors ?-lactamases. Despite structural mechanis...

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