background and objective : carbapenems are therapeutic choice against infections caused by gram-negative bacilli including strains of acinetobacter baumannii. resistance to these antibiotics is mediated by efflux pumps, porins, pbps and ß-lactamases. the aim of this study was to determine the possibility of existence of mbls, oxas and ges-1 betalactamase genes among clinical isolates of acineto...

2-AS: 2-(9-anthroyloxy)stearic acid 12-AS: 12-(9-anthroyloxy)stearic acid 25-NBD-cholesterol: 25-[N-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-methyl]amino]27norcholesterol DOPC: dioleoyl-sn-glycero-3-phosphocholine MβCD: methyl-β-cyclodextrin NBD: 7-nitrobenz-2-oxa-1,3-diazol-4-yl NBD-PE: N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-1,2-dipalmitoyl-sn-glycero-3-pho sphoethanolamine REES: red edge excitatio...

Supplementary data at JAC Online). An additional promoter was predicted by Softberry BPROM promoter prediction and consisted of the 235 box of IS18 and a 210 box separated by 13 bp (Figure S1, available as Supplementary data at JAC Online). 10 Interestingly , the TTCAAT 235 box identical to that from Baz (bla OXA-228) was adjacent to the left inverted repeat. OXA-228-like expression in isolate ...

To the Editor—The emergence of New Delhi metallo-beta-lactamase–1 (NDM1) in India, Pakistan, and the UK has sparked great fear of the threat posed by resistant microbial strains and by the use of antibiotics worldwide [1]. Thus far, NDM-1 carbapenemase has been detected in several countries in a diverse group of bacteria. Acinetobacter baumannii has emerged as one of the most troublesome pathog...

Enterobacteriaceae producing class D OXA-48 and OXA-48-like carbapenemases are an increasing concern. Detection is a diagnostic challenge because (i) some isolates are carbapenem susceptible and may go unrecognized, (ii) tests that detect carbapenem hydrolysis may be insensitive due to the relatively weak hydrolytic activity of these enzymes, (iii) the enzymes are not significantly inhibited by...

Enterobacteriaceae producing the OXA-48 carbapenemase are emerging worldwide, leaving few treatment options. Efficacy has been demonstrated in vivo with ceftazidime against a ceftazidime-susceptible OXA-48 isolate but not with imipenem despite maintaining susceptibility. The relationship between phenotype and in vivo efficacy was assessed for OXA-48 producers using humanized regimens of 2 g dor...

L-Ascorbic acid (AsA) and its metabolic precursors give rise to oxalic acid (OxA) found in calcium oxalate crystals in specialized crystal idioblast cells in plants; however, it is not known if AsA and OxA are synthesized within the crystal idioblast cell or transported in from surrounding mesophyll cells. Isolated developing crystal idioblasts from Pistia stratiotes were used to study the path...

Hepatocellular carcinoma (HCC) is generally believed to have low sensitivity to chemotherapeutic agents including oxaliplatin (OXA). Studies have demonstrated that gap junctions (GJs) composed of connexin (Cx) proteins have the potential to modulate drug chemosensitivity in multiple tumor cells. In the present study, we investigated the characteristics of Cx and GJs in HCC at both histologic an...

This is the first report of an Acinetobacter baumannii from clinical origin carrying the bla OXA-58 gene in Brazil. The isolate included in this study was from a patient during an outbreak in Porto Alegre, RS, Southern Brazil, in 2007. It was resistant to most of the beta-lactams tested, it has also the bla OXA-65 gene and the ISAbal sequence located upstream to both bla OXA genes detected and ...

The first outbreak of carbapenem-resistant Klebsiella pneumoniae isolates producing the plasmid-encoded carbapenem-hydrolyzing oxacillinase OXA-48 is reported. The 39 isolates belonged to two different clones and were collected at the University Hospital of Istanbul, Turkey, from May 2006 to February 2007, and they coproduced various beta-lactamases (SHV-12, OXA-9, and TEM-1 for clone A and CTX...