The major pathological feature of Parkinson’s disease (PD) is a progressive loss of dopamine-producing neurons of the substantia nigra pars compacta (SNc), resulting in a reduction of dopamine (DA) content in the target field of these neurons, the striatum (STR). The present evidences suggest that female sex hormones may influence the onset and severity of PD symptoms. PD is more prevalent in m...

Estrogen protects against increases in arterial pressure (AP) by acting on blood vessels and on cardiovascular centers in the brain. The mechanisms underlying the effects of estrogen in the brain stem, however, are not clear. The aim of the present study was to determine whether ovariectomy affects AP via the Rho/Rho-kinase pathway in the brain stem. We performed bilateral ovariectomy in 12-wee...

The role of estrogen and prolactin in high-fat (HF) dietary stimulation of carcinogen-induced mammary tumors was examined in female Sprague-Dawley rats. At 55 days of age, the rats were given injections i.v. of 5 mg of dimethylbenz(a)anthracene and, 5 days later, rats were sham- or bilaterally ovariectomized. Ten days after dimethylbenz(a)anthracene administration, the rats were placed on eithe...

Experimental osteopenia caused by ovariectomy in rats may reflect postmenopausal bone changes, which are the effect of osteogen deficiency. The aim of the present study was to investigate the effects of tibolone (0.25 mg/kg/day and 2.5 mg/kg po) administered for 4 weeks on the development of osteopenia caused by bilateral ovariectomy in 3-month-old female Wistar rats. The experiments were carri...

The purpose of this study was to compare the effects of aerobic, resistance, or combined exercise training on cardiovascular autonomic control and mortality in diabetic ovariectomized rats. Female Wistar rats were divided into one of five groups: euglycemic sedentary (ES), diabetic ovariectomized sedentary (DOS), diabetic ovariectomized aerobic-trained (DOTA), diabetic ovariectomized resistance...

OBJECTIVES Chronic increases in blood flow in resistance arteries induce outward remodeling associated with increased wall thickness and endothelium-mediated dilatation. This remodeling is essential for collateral arteries growth following occlusion of a large artery. As estrogens have a major role in this remodeling, we hypothesized that resveratrol, described as possessing phytoestrogen prope...

OBJECTIVE Melanocortin-4 receptor (MC4R) and agouti-related peptide (AgRP) are involved in energy homeostasis in the rat. The aim of the present study was to evaluate the expression of MC4R and AgRP mRNAs in arcuate nucleus (ARC) during long term malnutrition of female ovariectomized rats. MATERIALS AND METHODS Ten female ovariectomized rats were divided into two equal groups (n=6) of normal ...

introduction: obesity and visceral fat accumulation after menopause are associated with insulin resistance and cardiovascular diseases. we investigated the interactive effect of aerobic-resistance training and estrogen replacement therapy on visceral fat, omentin-1 and homa-ir in ovariectomized rats. materials and methods: fifty female wistar rats were ovariectomized (ovx) and divided into 5 gr...

Estradiol, a major form of estrogen, plays crucial role in various aspects brain function, including neuronal health, synaptic plasticity, and cognitive processes. Therefore, it is interest to investigate the histopathological changes rat following estradiol treatment unilateral bilateral ovariectomized rats, commonly used method induce estrogen deficiency study consequences hormonal changes. T...